STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdkThymidine kinase (PF00265); Thymidine kinase (PTHR11441); Protein involved in thymidine kinase activity and ATP binding. (239 aa)    
Predicted Functional Partners:
dut
dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.969
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.965
AEK23882.1
Cytidine aminohydrolase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
 
  
 0.930
AEK23672.1
AltName: Full=dCMP deaminase;Short=dCD; DEOXYCYTIDYLATE DEAMINASE (PTHR11086:SF2); CMP/dCMP deaminase, zinc-binding (PF00383); Undefined Gene3D domain (G3DSA:3.40.140.10); dCMP deaminase (PIRSF006019); Cytidine deaminase (PTHR11086); Cytidine deaminase-like (SSF53927); APOBEC/CMP deaminase, zinc-binding (PS00903); Protein involved in zinc ion binding, hydrolase activity, catalytic activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds.
  
 
 0.925
AEK23195.1
Possible secreted 5'-nucleotidase; N-terminus: SpI(LipoP); 1 transmembrane domain; 5'-Nucleotidase/apyrase (PR01607); Metallo-dependent phosphatases (SSF56300); 5'-Nucleotidase/apyrase (PTHR11575); Undefined Gene3D domain (G3DSA:3.60.21.10); Metallophosphoesterase (PF00149); 5'-Nucleotidase, conserved site (PS00785); Protein involved in hydrolase activity, nucleotide binding, hydrolase activity, acting on ester bonds, metal ion binding and nucleotide catabolic process; Belongs to the 5'-nucleotidase family.
 
  
  0.915
AEK24083.1
Uridine phosphorylase; Short=UrdPase;Short=UPase; Purine and uridine phosphorylases (SSF53167); Undefined Gene3D domain (G3DSA:3.40.50.1580); Nucleoside phosphorylase (PF01048); Nucleoside phosphorylase, family 1 (PTHR21234); PURINE NUCLEOSIDE PHOSPHORYLASE (PTHR21234:SF7); Protein involved in catalytic activity and nucleoside metabolic process.
     
 0.913
AEK24191.1
Inosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
  0.905
surE
Nucleoside 5'-monophosphate phosphohydrolase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.737
bioD
DTB synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
      0.648
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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