STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEN12366.1KEGG: sgr:SGR_2196 hypothetical protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit. (297 aa)    
Predicted Functional Partners:
AEN10245.1
KEGG: sgr:SGR_6690 putative ATP-dependent DNA ligase; TIGRFAM: DNA polymerase LigD, ligase domain protein; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein.
  
 0.999
AEN08491.1
TIGRFAM: DNA ligase D, 3'-phosphoesterase domain protein; KEGG: sgr:SGR_6488 hypothetical protein.
   
 0.993
ku-2
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.987
AEN13661.1
PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; KEGG: sco:SCO6707 ATP-dependent DNA ligase.
   
 0.970
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.909
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.901
AEN12365.1
PFAM: PBS lyase HEAT domain protein repeat-containing protein; KEGG: sgr:SGR_2197 hypothetical protein.
     
 0.588
AEN12364.1
KEGG: sgr:SGR_2198 hypothetical protein.
       0.566
AEN12363.1
PFAM: cell cycle protein; KEGG: sgr:SGR_2202 putative cell division membrane protein; Belongs to the SEDS family.
       0.478
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
      
 0.456
Your Current Organism:
Streptomyces sp. SirexAAE
NCBI taxonomy Id: 862751
Other names: S. sp. SirexAA-E, Streptomyces sp. ACTE, Streptomyces sp. SA3_actE, Streptomyces sp. SirexAA-E
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