node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGK95702.1 | AGK96154.1 | Clopa_0658 | Clopa_1159 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | 0.901 |
AGK95702.1 | AGK96286.1 | Clopa_0658 | Clopa_1299 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | PFAM: ACT domain; TIGRFAM: acetolactate synthase, small subunit. | 0.584 |
AGK95702.1 | AGK96292.1 | Clopa_0658 | Clopa_1306 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; PFAM: AMP-binding enzyme. | 0.727 |
AGK95702.1 | AGK98221.1 | Clopa_0658 | Clopa_3427 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases. | 0.643 |
AGK95702.1 | AGK99548.1 | Clopa_0658 | Clopa_4874 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | Dihydroxyacid dehydratase/phosphogluconate dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.592 |
AGK95702.1 | ilvC | Clopa_0658 | Clopa_2226 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.662 |
AGK95702.1 | ilvD | Clopa_0658 | Clopa_0502 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.592 |
AGK95702.1 | leuB | Clopa_0658 | Clopa_2229 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.643 |
AGK95702.1 | leuC | Clopa_0658 | Clopa_2227 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.824 |
AGK95702.1 | leuD | Clopa_0658 | Clopa_2228 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.825 |
AGK96154.1 | AGK95702.1 | Clopa_1159 | Clopa_0658 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | 0.901 |
AGK96154.1 | AGK96286.1 | Clopa_1159 | Clopa_1299 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | PFAM: ACT domain; TIGRFAM: acetolactate synthase, small subunit. | 0.584 |
AGK96154.1 | AGK96292.1 | Clopa_1159 | Clopa_1306 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; PFAM: AMP-binding enzyme. | 0.728 |
AGK96154.1 | AGK98221.1 | Clopa_1159 | Clopa_3427 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases. | 0.643 |
AGK96154.1 | AGK99548.1 | Clopa_1159 | Clopa_4874 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | Dihydroxyacid dehydratase/phosphogluconate dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.592 |
AGK96154.1 | ilvC | Clopa_1159 | Clopa_2226 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.662 |
AGK96154.1 | ilvD | Clopa_1159 | Clopa_0502 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.592 |
AGK96154.1 | leuB | Clopa_1159 | Clopa_2229 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.643 |
AGK96154.1 | leuC | Clopa_1159 | Clopa_2227 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.824 |
AGK96154.1 | leuD | Clopa_1159 | Clopa_2228 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.825 |