STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hptPhosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (190 aa)    
Predicted Functional Partners:
AEG17145.1
KEGG: mmg:MTBMA_c01210 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Fumarate lyase; Adenylosuccinate lyase, C-terminal; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.987
guaAB
GMP synthase (glutamine-hydrolyzing) subunit B; Catalyzes the synthesis of GMP from XMP.
  
 0.984
AEG17154.1
PfkB domain protein; PFAM: Carbohydrate/purine kinase; KEGG: mth:MTH1544 ribokinase; Belongs to the carbohydrate kinase PfkB family.
 
 0.980
guaAA
GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP.
  
 
 0.962
ade
Adenine deaminase; PFAM: Amidohydrolase 1; TIGRFAM: Adenine deaminase; HAMAP: Adenine deaminase; KEGG: mmg:MTBMA_c12610 adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
    
 0.934
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.926
AEG18863.1
Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
  
 
 0.923
purP
5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
    
  0.902
AEG17635.1
KEGG: mmg:MTBMA_c02420 adenylate kinase.
     
  0.900
adkA
KEGG: mmg:MTBMA_c05160 adenylate kinase; HAMAP: Adenylate kinase; Belongs to the archaeal adenylate kinase family.
     
  0.900
Your Current Organism:
Methanobacterium paludis
NCBI taxonomy Id: 868131
Other names: DSM 25820, JCM 18151, M. paludis, Methanobacterium paludis Cadillo-Quiroz et al. 2014, Methanobacterium sp. SWAN1, strain SWAN1
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