STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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Experiments
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Textmining
[Homology]
Score
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa)    
Predicted Functional Partners:
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 0.999
trpF
KEGG: drm:Dred_0252 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family.
  
 0.999
trpC
KEGG: drm:Dred_0251 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 
 0.999
AEF94538.1
TIGRFAM: Anthranilate synthase, glutamine amidotransferase domain; KEGG: drm:Dred_0249 glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal.
 
  
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
  
 0.995
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
  
 0.993
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 
 0.928
AEF92989.1
KEGG: drm:Dred_0097 threonine dehydratase; TIGRFAM: Threonine dehydratase II; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Amino acid-binding ACT.
  
 
 0.922
AEF94797.1
TIGRFAM: Serine dehydratase, alpha subunit; KEGG: drm:Dred_1253 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: Serine dehydratase-like, alpha subunit.
   
 
 0.904
AEF94798.1
TIGRFAM: Iron-sulphur-dependent L-serine dehydratase beta subunit; KEGG: drm:Dred_1252 L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: Serine dehydratase beta chain; Amino acid-binding ACT.
   
 
 0.904
Your Current Organism:
Desulfotomaculum nigrificans
NCBI taxonomy Id: 868595
Other names: D. nigrificans CO-1-SRB, Desulfotomaculum carboxydivorans CO-1-SRB, Desulfotomaculum carboxydivorans DSM 14880, Desulfotomaculum nigrificans CO-1-SRB
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