STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)    
Predicted Functional Partners:
ADY73771.1
ATP citrate synthase; COGs: COG0074 Succinyl-CoA synthetase alpha subunit; InterPro IPR003781: IPR005811; KEGG: pmx:PERMA_1714 ATP-citrate synthase (ATP-citrate (pro-S-)-lyase)(citrate cleavage enzyme); PFAM: ATP-citrate lyase/succinyl-CoA ligase; CoA-binding; PRIAM: ATP citrate synthase; SPTR: ATP-citrate synthase (ATP-citrate (Pro-S-)-lyase)(Citrate cleavage enzyme); PFAM: CoA-ligase; Citrate synthase.
  
 0.999
ADY73383.1
Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; COGs: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I N-terminal domain; InterPro IPR004646; KEGG: aae:aq_1780 fumarate hydratase; PFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; PRIAM: Fumarate hydratase; SPTR: Fumarate hydratase (Fumarase); TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; PFAM: Fumarate hydratase (Fumerase); TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region.
  
 
 0.992
ADY73303.1
Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; COGs: COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I C-terminal domain; InterPro IPR004647; KEGG: nam:NAMH_1232 C-terminal fumarate hydratase, class I; PFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; PRIAM: Fumarate hydratase; SPTR: C-terminal fumarate hydratase, class I; TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; PFAM: Fumarase C-terminus; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region.
  
 
 0.968
ADY73772.1
ATP-grasp domain protein; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650; KEGG: pmx:PERMA_1715 ATP-citrate synthase (ATP-citrate (pro-S-)-lyase)(citrate cleavage enzyme); PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; SPTR: ATP citrate lyase beta subunit; PFAM: ATP-grasp domain.
  
 0.959
ADY73773.1
Isocitrate dehydrogenase, NADP-dependent; COGs: COG2838 Monomeric isocitrate dehydrogenase; InterPro IPR004436; KEGG: sul:SYO3AOP1_0694 isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: Isocitrate dehydrogenase [NADP]; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; PFAM: Monomeric isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family.
  
  
 0.954
ADY73983.1
Oxaloacetate decarboxylase alpha subunit; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR005776: IPR000891: IPR003379: IPR000089; KEGG: pmx:PERMA_0625 pyruvate carboxylase subunit B; PFAM: Carboxylase, conserved domain; Pyruvate carboxyltransferase; Biotin/lipoyl attachment; PRIAM: Pyruvate carboxylase; SPTR: Oxaloacetate decarboxylase alpha subunit; TIGRFAM: Oxaloacetate decarboxylase, alpha subunit; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; TIGRFAM: oxaloacetate decarboxylase alpha subunit.
    
 0.950
ADY73752.1
COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: aae:aq_1969 aspartate aminotransferase; PFAM: Aminotransferase, class I/II; PRIAM: Aspartate transaminase; SPTR: Aspartate aminotransferase; PFAM: Aminotransferase class I and II.
  
 0.917
ADY73982.1
acetyl-CoA carboxylase, biotin carboxylase; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR004549: IPR005481: IPR005479: IPR005482; KEGG: aae:aq_1470 biotin carboxylase; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Biotin carboxylase, C-terminal; PRIAM: Pyruvate carboxylase; SPTR: Biotin carboxylase; TIGRFAM: Acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L [...]
     
 0.908
ADY72827.1
KEGG: tai:Taci_0967 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Putative pyruvate ferredoxin oxidoreductase, iron-sulfur binding subunit.
  
  
 0.887
ADY72889.1
COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583: IPR006982: IPR002932: IPR002489; KEGG: hth:HTH_0871 ferredoxin-dependent glutamate synthase; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Ferredoxin-dependent glutamate synthase; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
  
 
 0.886
Your Current Organism:
Desulfurobacterium thermolithotrophum
NCBI taxonomy Id: 868864
Other names: D. thermolithotrophum DSM 11699, Desulfurobacterium thermolithotrophum BSA, Desulfurobacterium thermolithotrophum DSM 11699, Desulfurobacterium thermolithotrophum str. DSM 11699, Desulfurobacterium thermolithotrophum strain DSM 11699
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