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hisE protein (Desulfurobacterium thermolithotrophum) - STRING interaction network
"hisE" - COGs: COG0140 Phosphoribosyl-ATP pyrophosphohydrolase in Desulfurobacterium thermolithotrophum
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisECOGs- COG0140 Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP- Phosphoribosyl-ATP pyrophosphohydrolase; InterPro IPR021130- IPR008179; KEGG- pmx-PERMA_0366 histidine biosynthesis bifunctional protein hisIE; PFAM- Phosphoribosyl-ATP pyrophosphohydrolase-like; SPTR- Histidine biosynthesis bifunctional protein hisIE; TIGRFAM- Phosphoribosyl-ATP pyrophosphohydrolase; PFAM- Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM- phosphoribosyl-ATP pyrophosphohydrolase (96 aa)    
Predicted Functional Partners:
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (117 aa)
   
  0.999
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Short subfamily (211 aa)
 
 
  0.988
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COGs- COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP-1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062- IPR006063; KEGG- pmx-PERMA_1646 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase; PFAM- Histidine biosynthesis; PRIAM-1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomer [...] (240 aa)
   
  0.973
hisZ
ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (422 aa)
 
   
  0.944
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (251 aa)
   
  0.929
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (441 aa)
 
   
  0.918
hisB
COGs- COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP- Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG- gur-Gura_4056 imidazoleglycerol-phosphate dehydratase; PFAM- Imidazoleglycerol-phosphate dehydratase; PRIAM- Imidazoleglycerol-phosphate dehydratase; SPTR- Imidazoleglycerol-phosphate dehydratase; PFAM- Imidazoleglycerol-phosphate dehydratase (194 aa)
 
   
  0.862
ADY73743.1
InterPro IPR005632; KEGG- ppd-Ppro_3018 outer membrane chaperone Skp (OmpH); PFAM- Outer membrane chaperone Skp (OmpH); SPTR- Outer membrane chaperone Skp (OmpH); PFAM- Outer membrane protein (OmpH-like) (178 aa)
              0.845
lpxD
UDP-3-O-acylglucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily (334 aa)
              0.845
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (419 aa)
              0.845
Your Current Organism:
Desulfurobacterium thermolithotrophum
NCBI taxonomy Id: 868864
Other names: D. thermolithotrophum DSM 11699, Desulfurobacterium thermolithotrophum, Desulfurobacterium thermolithotrophum BSA, Desulfurobacterium thermolithotrophum DSM 11699, Desulfurobacterium thermolithotrophum DSM11699, Desulfurobacterium thermolithotrophum str. DSM 11699, Desulfurobacterium thermolithotrophum strain DSM 11699
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