STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB12111.1COGs: COG4956 Integral membrane protein (PIN domain superfamily); InterPro IPR002716:IPR002792:IPR006596; KEGG: opr:Ocepr_1023 PilT protein domain protein; PFAM: PilT protein, N-terminal; Deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein, PINc; SPTR: PilT protein domain protein; IMG reference gene:2504660975; PFAM: TRAM domain; PIN domain. (338 aa)    
Predicted Functional Partners:
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.903
AEB12113.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR013093:IPR019489:IPR 003593; KEGG: msv:Mesil_2175 ATPase AAA-2 domain protein; PFAM: ATPase, AAA-2; ATPase, AAA-type, core; Clp, N-terminal; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 domain protein; manually curated; IMG reference gene:2504660977; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); Belongs to [...]
  
    0.754
AEB12108.1
MazG nucleotide pyrophosphohydrolase; InterPro IPR004518; KEGG: ttj:TTHA0898 hypothetical protein; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core; SPTR: Hypothetical cytosolic protein; IMG reference gene:2504660972; PFAM: MazG nucleotide pyrophosphohydrolase domain.
 
     0.586
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
  
    0.538
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
       0.501
sucC
Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
       0.501
glyQ
COGs: COG0752 Glycyl-tRNA synthetase alpha subunit; HAMAP: Glycyl-tRNA synthetase, class IIc, alpha subunit; InterPro IPR002310; KEGG: opr:Ocepr_1020 glycyl-tRNA synthetase alpha chain; PFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit; PRIAM: Glycine--tRNA ligase; SPTR: Glycyl-tRNA synthetase, alpha subunit; TIGRFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit; IMG reference gene:2504660978; PFAM: Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, alpha subunit.
       0.476
glyS
COGs: COG0751 Glycyl-tRNA synthetase beta subunit; InterPro IPR002311:IPR008909:IPR015944; KEGG: opr:Ocepr_1019 glycyl-tRNA synthetase, beta subunit; PFAM: Glycyl-tRNA synthetase, class IIc, beta subunit, N-terminal; DALR anticodon binding; PRIAM: Glycine--tRNA ligase; SPTR: Glycyl-tRNA synthetase, beta subunit; TIGRFAM: Glycyl-tRNA synthetase, class IIc, beta subunit; IMG reference gene:2504660979; PFAM: Glycyl-tRNA synthetase beta subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, beta subunit.
       0.467
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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