node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ade | apt | shn_13270 | shn_12965 | Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.988 |
ade | guaA | shn_13270 | shn_22140 | Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.506 |
ade | shn_00235 | shn_13270 | shn_00235 | Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.906 |
ade | shn_15870 | shn_13270 | shn_15870 | Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.906 |
ade | shn_17740 | shn_13270 | shn_17740 | Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.964 |
ade | shn_21030 | shn_13270 | shn_21030 | Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.962 |
apt | ade | shn_12965 | shn_13270 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | 0.988 |
apt | gmk | shn_12965 | shn_06350 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.971 |
apt | guaA | shn_12965 | shn_22140 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.989 |
apt | purA | shn_12965 | shn_14945 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.547 |
apt | purH | shn_12965 | shn_19845 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.952 |
apt | shn_00235 | shn_12965 | shn_00235 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.948 |
apt | shn_15870 | shn_12965 | shn_15870 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.948 |
apt | shn_17740 | shn_12965 | shn_17740 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.927 |
apt | shn_21030 | shn_12965 | shn_21030 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.971 |
gmk | apt | shn_06350 | shn_12965 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.971 |
gmk | guaA | shn_06350 | shn_22140 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.987 |
gmk | guaB | shn_06350 | shn_03460 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.568 |
gmk | purA | shn_06350 | shn_14945 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.477 |
gmk | shn_17740 | shn_06350 | shn_17740 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.976 |