STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEL24223.1PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase; COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804:IPR014273; KEGG: tra:Trad_1633 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; SPTR: Isocitrate dehydrogenase; TIGRFAM: Isocitrate dehydrogenase bacteria. (488 aa)    
Predicted Functional Partners:
AEL24118.1
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.950
AEL26243.1
2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component; COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR011603:IPR001017:IPR005475; KEGG: chu:CHU_3362 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component; SPTR: Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component.
 
 0.932
AEL23893.1
2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752:IPR002880; KEGG: gpb:HDN1F_09550 2-ketoglutarate: nadp oxidoreductase, alpha subunit; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; SPTR: 2-ketoglutarate: nadp oxidoreductase, alpha subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreducta [...]
     
 0.910
AEL26233.1
PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; COGs: COG1049 Aconitase B; InterPro IPR015929:IPR001030; KEGG: cao:Celal_2440 aconitase; PFAM: Aconitase B, N-terminal, bacterial; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; SPTR: Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase.
    
 0.908
AEL25632.1
PFAM: Monomeric isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, monomeric type; COGs: COG2838 Monomeric isocitrate dehydrogenase; InterPro IPR004436; KEGG: mtt:Ftrac_3556 isocitrate dehydrogenase, nADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; SPTR: Isocitrate dehydrogenase [NADP]; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family.
    
 0.907
AEL23894.1
Thiamine pyrophosphate TPP-binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: gpb:HDN1F_09560 2-ketoglutarate: NADP oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; SPTR: 2-ketoglutarate: NADP oxidoreductase, beta subunit.
   
 
 0.902
AEL25511.1
PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: mtt:Ftrac_2525 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; SPTR: Ferredoxin-dependent glutamate synthase 1.
  
 
 0.896
argH
PFAM: Lyase; TIGRFAM: argininosuccinate lyase; COGs: COG0165 Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; InterPro IPR000362:IPR009049; KEGG: mtt:Ftrac_1535 argininosuccinate lyase; PFAM: Fumarate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: Argininosuccinate lyase.
  
 
 0.841
AEL24929.1
PFAM: Aldehyde dehydrogenase family; COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590; KEGG: aldehyde dehydrogenase (NADP(+)); PFAM: Aldehyde dehydrogenase; SPTR: NADP-dependent fatty aldehyde dehydrogenase.
   
 0.820
AEL26782.1
PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097:IPR006096; KEGG: mtt:Ftrac_1884 glutamate dehydrogenase (nadp); PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region; SPTR: Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 
 0.820
Your Current Organism:
Cyclobacterium marinum
NCBI taxonomy Id: 880070
Other names: C. marinum DSM 745, Cyclobacterium marinum DSM 745, Cyclobacterium marinum LMG 13164, Cyclobacterium marinum str. DSM 745, Cyclobacterium marinum strain DSM 745
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.