STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa)    
Predicted Functional Partners:
EFV02622.1
Putative TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase; COG: COG1249; overlaps another CDS with the same product name.
   
 0.999
EFV02623.1
Pyridine nucleotide-disulfide oxidoreductase, dimerization domain protein; COG: COG1249; overlaps another CDS with the same product name.
   
 0.999
EFV01769.1
Putative UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; COG: COG1207.
  
 0.966
EFV02864.1
Transketolase, C-terminal domain protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
   
 0.955
EFV02619.1
Transketolase, pyridine binding domain protein; COG: COG0022.
   
 0.955
pth
aminoacyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
 
 
 0.870
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
  
 
 0.839
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.835
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 0.833
lysS
lysine--tRNA ligase; COG: COG1190; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 
 0.830
Your Current Organism:
Pseudoramibacter alactolyticus
NCBI taxonomy Id: 887929
Other names: P. alactolyticus ATCC 23263, Pseudoramibacter alactolyticus ATCC 23263, Pseudoramibacter alactolyticus str. ATCC 23263, Pseudoramibacter alactolyticus strain ATCC 23263
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