STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfkAATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (335 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; COG: COG0166; Belongs to the GPI family
  
 0.998
fba
Fructose-1,6-bisphosphate aldolase, class II; COG: COG0191
  
 
 0.994
pyk
Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family
 
 0.984
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family
 
 
 0.946
EFU63048.1
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1299
    
 0.937
eno
Enolase; Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family
  
  
 0.924
tkt
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
  
 
 0.905
pfkB
Tagatose-6-phosphate kinase; COG: COG1105; Belongs to the carbohydrate kinase PfkB family. LacC subfamily
     
 0.902
dnaE
DNA-directed DNA polymerase; COG: COG0587
    
  0.885
glgP
Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
  
 0.883
Your Current Organism:
Streptococcus oralis ATCC49296
NCBI taxonomy Id: 888049
Other names: S. oralis ATCC 49296, Streptococcus oralis ATCC 49296, Streptococcus oralis ATCC49296
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