| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00215 | ISM_04775 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.959 |
| ISM_00215 | ISM_05545 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.964 |
| ISM_00215 | ISM_05910 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.987 |
| ISM_00215 | ISM_06925 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.996 |
| ISM_00215 | ISM_09291 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Hypothetical protein; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.668 |
| ISM_00215 | ISM_09296 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Putative two-component sensor histidine kinase protein; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.748 |
| ISM_00215 | ISM_11185 | Hypothetical protein; COG2199 FOG: GGDEF domain. | C4-dicarboxylate transport transcriptional regulatory protein DctD; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.668 |
| ISM_00215 | ISM_13495 | Hypothetical protein; COG2199 FOG: GGDEF domain. | C4-dicarboxylate transport sensor protein DctB, putative; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.749 |
| ISM_00215 | ISM_13500 | Hypothetical protein; COG2199 FOG: GGDEF domain. | C4-dicarboxylate transport transcriptional regulatory protein DctD; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.668 |
| ISM_04775 | ISM_00215 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.959 |
| ISM_04775 | ISM_05545 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.842 |
| ISM_04775 | ISM_05910 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.976 |
| ISM_04775 | ISM_06925 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.998 |
| ISM_04775 | ISM_09291 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Hypothetical protein; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.565 |
| ISM_04775 | ISM_09296 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Putative two-component sensor histidine kinase protein; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.659 |
| ISM_04775 | ISM_11185 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | C4-dicarboxylate transport transcriptional regulatory protein DctD; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.565 |
| ISM_04775 | ISM_13495 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | C4-dicarboxylate transport sensor protein DctB, putative; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.659 |
| ISM_04775 | ISM_13500 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | C4-dicarboxylate transport transcriptional regulatory protein DctD; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.624 |
| ISM_05545 | ISM_00215 | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.964 |
| ISM_05545 | ISM_04775 | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.842 |