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GH protein (Gallus gallus) - STRING interaction network
"GH" - Somatotropin in Gallus gallus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GHSomatotropin; Growth hormone plays an important role in growth control (216 aa)    
Predicted Functional Partners:
PRL
Prolactin; Gallus gallus prolactin (PRL), mRNA (229 aa)
     
0.986
GHR
Growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily (608 aa)
       
  0.985
PRLR
Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily (831 aa)
     
  0.967
GHRL
Gallus gallus ghrelin/obestatin prepropeptide (GHRL), mRNA (116 aa)
         
  0.942
JAK2
Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1193 aa)
         
  0.923
STAT5B
Gallus gallus signal transducer and activator of transcription 5B (STAT5B), mRNA (787 aa)
         
  0.915
FSHB
Gallus gallus follicle stimulating hormone, beta polypeptide (FSHB), mRNA (131 aa)
     
   
  0.910
MAPK1
Mitogen-activated protein kinase 1 (320 aa)
       
  0.902
BTRC
Beta-transducin repeat containing E3 ubiquitin protein ligase (605 aa)
         
    0.900
LYN
Tyrosine-protein kinase; Gallus gallus v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (LYN), mRNA (492 aa)
         
    0.900
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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