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MAP2K2 protein (Gallus gallus) - STRING interaction network
"MAP2K2" - Dual specificity mitogen-activated protein kinase kinase 2 in Gallus gallus
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity) (398 aa)    
Predicted Functional Partners:
BRAF
Serine/threonine-protein kinase B-raf; May play a role in transducing specific signals in neural cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily (760 aa)
     
0.990
MAPK1
Mitogen-activated protein kinase 1 (320 aa)
   
0.988
KSR2
Kinase suppressor of ras 2 (917 aa)
     
  0.987
KSR1
Kinase suppressor of ras 1 (930 aa)
     
  0.984
RAF1
RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity) (647 aa)
     
0.978
HRAS
GTPase HRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family (189 aa)
     
  0.973
KRAS
KRAS proto-oncogene, GTPase; Gallus gallus v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), mRNA (188 aa)
     
  0.972
PTPN11
Tyrosine-protein phosphatase non-receptor type 11; This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation (593 aa)
     
  0.958
SRC
Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy be [...] (533 aa)
     
0.934
RAP1B
Ras-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity) (184 aa)
     
  0.931
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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