STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GUCA1BGuanylyl cyclase-activating protein 2; Stimulates synthesis of cGMP in photoreceptors. Thought to mediate Ca(2+)-sensitive regulation of retinal guanylyl cyclase (GC), a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). (307 aa)    
Predicted Functional Partners:
GUCY2D
Guanylate cyclase.
   
 
 0.717
GUCA1A
Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure.
   
 
0.710
GNGT2
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
   
  
 0.696
CPLX4
Complexin 4.
   
  
 0.693
GNAT2
Uncharacterized protein.
   
 
 0.673
LOC107055115
Guanylate cyclase.
   
 
 0.655
NPR2
Guanylate cyclase.
   
 
 0.642
KCNV2
Potassium voltage-gated channel modifier subfamily V member 2; Belongs to the potassium channel family.
   
 
 0.626
GUCY2C
Guanylate cyclase.
   
 
 0.622
KIF3A
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
      
 0.612
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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