node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRL2 | FLRT3 | ENSGALP00000056097 | ENSGALP00000014168 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | Leucine-rich repeat transmembrane protein FLRT3; Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development. Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. M [...] | 0.855 |
ADGRL2 | TENM2 | ENSGALP00000056097 | ENSGALP00000074067 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | 0.986 |
ADGRL3 | FLRT3 | ENSGALP00000043995 | ENSGALP00000014168 | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | Leucine-rich repeat transmembrane protein FLRT3; Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development. Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. M [...] | 0.981 |
ADGRL3 | TENM2 | ENSGALP00000043995 | ENSGALP00000074067 | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | 0.745 |
C1QBP | TENM2 | ENSGALP00000002522 | ENSGALP00000074067 | Complement C1q binding protein. | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | 0.601 |
EGF | FURIN | ENSGALP00000044972 | ENSGALP00000013566 | Uncharacterized protein. | Trans Golgi network protease furin; Belongs to the peptidase S8 family. | 0.595 |
EGF | TENM2 | ENSGALP00000044972 | ENSGALP00000074067 | Uncharacterized protein. | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | 0.576 |
EPHB1 | TENM2 | ENSGALP00000010654 | ENSGALP00000074067 | Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a role in axon guidance during nervous system development. May also play an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines [...] | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | 0.541 |
FLRT3 | ADGRL2 | ENSGALP00000014168 | ENSGALP00000056097 | Leucine-rich repeat transmembrane protein FLRT3; Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development. Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. M [...] | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | 0.855 |
FLRT3 | ADGRL3 | ENSGALP00000014168 | ENSGALP00000043995 | Leucine-rich repeat transmembrane protein FLRT3; Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development. Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. M [...] | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | 0.981 |
FLRT3 | TENM2 | ENSGALP00000014168 | ENSGALP00000074067 | Leucine-rich repeat transmembrane protein FLRT3; Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development. Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. M [...] | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | 0.762 |
FURIN | EGF | ENSGALP00000013566 | ENSGALP00000044972 | Trans Golgi network protease furin; Belongs to the peptidase S8 family. | Uncharacterized protein. | 0.595 |
FURIN | TENM2 | ENSGALP00000013566 | ENSGALP00000074067 | Trans Golgi network protease furin; Belongs to the peptidase S8 family. | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | 0.573 |
KCTD21 | TENM2 | ENSGALP00000027865 | ENSGALP00000074067 | Potassium channel tetramerization domain containing 21. | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | 0.539 |
TENM2 | ADGRL2 | ENSGALP00000074067 | ENSGALP00000056097 | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | 0.986 |
TENM2 | ADGRL3 | ENSGALP00000074067 | ENSGALP00000043995 | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | 0.745 |
TENM2 | C1QBP | ENSGALP00000074067 | ENSGALP00000002522 | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | Complement C1q binding protein. | 0.601 |
TENM2 | EGF | ENSGALP00000074067 | ENSGALP00000044972 | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | Uncharacterized protein. | 0.576 |
TENM2 | EPHB1 | ENSGALP00000074067 | ENSGALP00000010654 | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a role in axon guidance during nervous system development. May also play an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines [...] | 0.541 |
TENM2 | FLRT3 | ENSGALP00000074067 | ENSGALP00000014168 | Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. | Leucine-rich repeat transmembrane protein FLRT3; Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development. Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. M [...] | 0.762 |