node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COX5B | GRPEL1 | ENSGALP00000056589 | ENSGALP00000064381 | Cytochrome c oxidase subunit 5B. | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. | 0.858 |
COX5B | GRPEL2 | ENSGALP00000056589 | ENSGALP00000069779 | Cytochrome c oxidase subunit 5B. | GrpE like 2, mitochondrial. | 0.866 |
COX5B | HSPA9 | ENSGALP00000056589 | ENSGALP00000003717 | Cytochrome c oxidase subunit 5B. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | 0.935 |
COX5B | TIMM17B | ENSGALP00000056589 | ENSGALP00000000122 | Cytochrome c oxidase subunit 5B. | Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. | 0.939 |
COX5B | TIMM23B | ENSGALP00000056589 | ENSGALP00000003252 | Cytochrome c oxidase subunit 5B. | Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. | 0.989 |
COX5B | VDAC1 | ENSGALP00000056589 | ENSGALP00000043741 | Cytochrome c oxidase subunit 5B. | Uncharacterized protein. | 0.408 |
DNAJA3 | GRPEL1 | ENSGALP00000072822 | ENSGALP00000064381 | DnaJ heat shock protein family (Hsp40) member A3. | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. | 0.718 |
DNAJA3 | GRPEL2 | ENSGALP00000072822 | ENSGALP00000069779 | DnaJ heat shock protein family (Hsp40) member A3. | GrpE like 2, mitochondrial. | 0.713 |
DNAJA3 | HSPA9 | ENSGALP00000072822 | ENSGALP00000003717 | DnaJ heat shock protein family (Hsp40) member A3. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | 0.981 |
DNAJA3 | HSPD1 | ENSGALP00000072822 | ENSGALP00000013122 | DnaJ heat shock protein family (Hsp40) member A3. | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] | 0.720 |
DNAJA3 | TIMM17B | ENSGALP00000072822 | ENSGALP00000000122 | DnaJ heat shock protein family (Hsp40) member A3. | Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. | 0.509 |
DNAJA3 | TIMM44 | ENSGALP00000072822 | ENSGALP00000000471 | DnaJ heat shock protein family (Hsp40) member A3. | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | 0.702 |
DNLZ | HSPA9 | ENSGALP00000073900 | ENSGALP00000003717 | DNL-type zinc finger. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | 0.910 |
DNLZ | TIMM17B | ENSGALP00000073900 | ENSGALP00000000122 | DNL-type zinc finger. | Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. | 0.523 |
DNLZ | TIMM44 | ENSGALP00000073900 | ENSGALP00000000471 | DNL-type zinc finger. | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | 0.534 |
GRPEL1 | COX5B | ENSGALP00000064381 | ENSGALP00000056589 | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. | Cytochrome c oxidase subunit 5B. | 0.858 |
GRPEL1 | DNAJA3 | ENSGALP00000064381 | ENSGALP00000072822 | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. | DnaJ heat shock protein family (Hsp40) member A3. | 0.718 |
GRPEL1 | GRPEL2 | ENSGALP00000064381 | ENSGALP00000069779 | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. | GrpE like 2, mitochondrial. | 0.587 |
GRPEL1 | HSPA9 | ENSGALP00000064381 | ENSGALP00000003717 | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | 0.953 |
GRPEL1 | HSPD1 | ENSGALP00000064381 | ENSGALP00000013122 | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] | 0.775 |