STRINGSTRING
TLN1 protein (Gallus gallus) - STRING interaction network
"TLN1" - Talin-1 in Gallus gallus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
TLN1Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell- substratum contact and, in lymphocytes, at cell-cell contacts (2541 aa)    
Predicted Functional Partners:
VCL
Vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family (1042 aa)
     
  0.999
APBB1IP
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling (659 aa)
     
  0.987
PXN
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK (555 aa)
     
  0.984
PIP5K1C
Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (679 aa)
     
  0.983
ITGB3
Gallus gallus integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3), mRNA (781 aa)
     
  0.974
RAP1B
Ras-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity) (184 aa)
       
  0.959
PTK2
Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous s [...] (1051 aa)
     
  0.958
RAP1A
RAP1A, member of RAS oncogene family (188 aa)
       
  0.947
ITGB5
Gallus gallus integrin, beta 5 (ITGB5), mRNA (812 aa)
     
  0.946
BCAR1
BCAR1, Cas family scaffolding protein; Breast cancer anti-estrogen resistance 1 (927 aa)
     
 
  0.939
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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