RGS4 protein (Gallus gallus) - STRING interaction network

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RGS4

Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity). (209 aa)

Predicted Functional Partners:

RGS3-2

0.967

GNAI3

0.873

GNAI1

0.742

GNAI2

0.742

GNAT3

0.701

RGS5

0.690

GNAQ

0.671

GNA11

0.632

GNB5

0.621

RGS7

0.615

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNA11	GNAI1	ENSGALP00000005115	ENSGALP00000044195	Guanine nucleotide-binding protein G11 alpha-subunit.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.574
GNA11	GNAI2	ENSGALP00000005115	ENSGALP00000072608	Guanine nucleotide-binding protein G11 alpha-subunit.	Guanine nucleotide-binding protein G(i) subunit alpha-2.	0.574
GNA11	GNAI3	ENSGALP00000005115	ENSGALP00000062750	Guanine nucleotide-binding protein G11 alpha-subunit.	G protein alpha subunit.	0.568
GNA11	GNAQ	ENSGALP00000005115	ENSGALP00000024446	Guanine nucleotide-binding protein G11 alpha-subunit.	Uncharacterized protein.	0.902
GNA11	GNAT3	ENSGALP00000005115	ENSGALP00000013713	Guanine nucleotide-binding protein G11 alpha-subunit.	Uncharacterized protein.	0.562
GNA11	GNB5	ENSGALP00000005115	ENSGALP00000048497	Guanine nucleotide-binding protein G11 alpha-subunit.	WD_REPEATS_REGION domain-containing protein.	0.797
GNA11	RGS4	ENSGALP00000005115	ENSGALP00000004041	Guanine nucleotide-binding protein G11 alpha-subunit.	Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).	0.632
GNA11	RGS5	ENSGALP00000005115	ENSGALP00000042833	Guanine nucleotide-binding protein G11 alpha-subunit.	Regulator of G protein signaling 5.	0.603
GNAI1	GNA11	ENSGALP00000044195	ENSGALP00000005115	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Guanine nucleotide-binding protein G11 alpha-subunit.	0.574
GNAI1	GNAI2	ENSGALP00000044195	ENSGALP00000072608	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Guanine nucleotide-binding protein G(i) subunit alpha-2.	0.902
GNAI1	GNAI3	ENSGALP00000044195	ENSGALP00000062750	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	G protein alpha subunit.	0.905
GNAI1	GNAQ	ENSGALP00000044195	ENSGALP00000024446	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Uncharacterized protein.	0.560
GNAI1	GNAT3	ENSGALP00000044195	ENSGALP00000013713	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Uncharacterized protein.	0.572
GNAI1	GNB5	ENSGALP00000044195	ENSGALP00000048497	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	WD_REPEATS_REGION domain-containing protein.	0.815
GNAI1	RGS4	ENSGALP00000044195	ENSGALP00000004041	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).	0.742
GNAI1	RGS5	ENSGALP00000044195	ENSGALP00000042833	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Regulator of G protein signaling 5.	0.615
GNAI1	RGS7	ENSGALP00000044195	ENSGALP00000056064	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Uncharacterized protein.	0.671
GNAI2	GNA11	ENSGALP00000072608	ENSGALP00000005115	Guanine nucleotide-binding protein G(i) subunit alpha-2.	Guanine nucleotide-binding protein G11 alpha-subunit.	0.574
GNAI2	GNAI1	ENSGALP00000072608	ENSGALP00000044195	Guanine nucleotide-binding protein G(i) subunit alpha-2.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.902
GNAI2	GNAI3	ENSGALP00000072608	ENSGALP00000062750	Guanine nucleotide-binding protein G(i) subunit alpha-2.	G protein alpha subunit.	0.909

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