node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRLS1 | PISD | ENSGALP00000069526 | ENSGALP00000011112 | Cardiolipin synthase 1. | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. | 0.969 |
CRLS1 | PRELID1 | ENSGALP00000069526 | ENSGALP00000004724 | Cardiolipin synthase 1. | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (By similarity). May be involved in hematopoiesis during avian development. | 0.603 |
CRLS1 | TAMM41 | ENSGALP00000069526 | ENSGALP00000073574 | Cardiolipin synthase 1. | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. | 0.635 |
CRLS1 | TRIAP1 | ENSGALP00000069526 | ENSGALP00000011638 | Cardiolipin synthase 1. | Uncharacterized protein. | 0.466 |
LONP1 | NDUFA9 | ENSGALP00000045450 | ENSGALP00000047989 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. | Epimerase domain-containing protein. | 0.417 |
LONP1 | OMA1 | ENSGALP00000045450 | ENSGALP00000017638 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. | OMA1 zinc metallopeptidase. | 0.496 |
LONP1 | PRELID1 | ENSGALP00000045450 | ENSGALP00000004724 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (By similarity). May be involved in hematopoiesis during avian development. | 0.626 |
LONP1 | TIMM17B | ENSGALP00000045450 | ENSGALP00000000122 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. | Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. | 0.570 |
NDUFA9 | LONP1 | ENSGALP00000047989 | ENSGALP00000045450 | Epimerase domain-containing protein. | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. | 0.417 |
NDUFA9 | PRELID1 | ENSGALP00000047989 | ENSGALP00000004724 | Epimerase domain-containing protein. | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (By similarity). May be involved in hematopoiesis during avian development. | 0.534 |
NDUFA9 | TIMM17B | ENSGALP00000047989 | ENSGALP00000000122 | Epimerase domain-containing protein. | Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. | 0.825 |
NDUFA9 | TOMM20 | ENSGALP00000047989 | ENSGALP00000053446 | Epimerase domain-containing protein. | Translocase of outer mitochondrial membrane 20. | 0.490 |
OMA1 | LONP1 | ENSGALP00000017638 | ENSGALP00000045450 | OMA1 zinc metallopeptidase. | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. | 0.496 |
OMA1 | PRELID1 | ENSGALP00000017638 | ENSGALP00000004724 | OMA1 zinc metallopeptidase. | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (By similarity). May be involved in hematopoiesis during avian development. | 0.656 |
OMA1 | TIMM17B | ENSGALP00000017638 | ENSGALP00000000122 | OMA1 zinc metallopeptidase. | Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. | 0.514 |
OMA1 | TOMM20 | ENSGALP00000017638 | ENSGALP00000053446 | OMA1 zinc metallopeptidase. | Translocase of outer mitochondrial membrane 20. | 0.449 |
PISD | CRLS1 | ENSGALP00000011112 | ENSGALP00000069526 | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. | Cardiolipin synthase 1. | 0.969 |
PISD | PRELID1 | ENSGALP00000011112 | ENSGALP00000004724 | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (By similarity). May be involved in hematopoiesis during avian development. | 0.543 |
PISD | TAMM41 | ENSGALP00000011112 | ENSGALP00000073574 | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. | 0.476 |
PISD | TRIAP1 | ENSGALP00000011112 | ENSGALP00000011638 | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. | Uncharacterized protein. | 0.557 |