node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | CCNA2 | ENSGALP00000027497 | ENSGALP00000019361 | Cyclin A1; Belongs to the cyclin family. | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | 0.936 |
CCNA1 | CDK2 | ENSGALP00000027497 | ENSGALP00000056613 | Cyclin A1; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
CCNA1 | E2F1 | ENSGALP00000027497 | ENSGALP00000004806 | Cyclin A1; Belongs to the cyclin family. | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] | 0.992 |
CCNA1 | E2F2 | ENSGALP00000027497 | ENSGALP00000067798 | Cyclin A1; Belongs to the cyclin family. | E2F_TDP domain-containing protein. | 0.955 |
CCNA1 | E2F3 | ENSGALP00000027497 | ENSGALP00000036527 | Cyclin A1; Belongs to the cyclin family. | E2F transcription factor 3. | 0.951 |
CCNA1 | RB1 | ENSGALP00000027497 | ENSGALP00000071459 | Cyclin A1; Belongs to the cyclin family. | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] | 0.978 |
CCNA1 | RBL1 | ENSGALP00000027497 | ENSGALP00000069796 | Cyclin A1; Belongs to the cyclin family. | RB transcriptional corepressor like 1. | 0.696 |
CCNA1 | RBL2 | ENSGALP00000027497 | ENSGALP00000061242 | Cyclin A1; Belongs to the cyclin family. | Uncharacterized protein. | 0.696 |
CCNA1 | TFDP1 | ENSGALP00000027497 | ENSGALP00000027109 | Cyclin A1; Belongs to the cyclin family. | Transcription factor. | 0.590 |
CCNA1 | TFDP2 | ENSGALP00000027497 | ENSGALP00000055400 | Cyclin A1; Belongs to the cyclin family. | Uncharacterized protein. | 0.569 |
CCNA2 | CCNA1 | ENSGALP00000019361 | ENSGALP00000027497 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Cyclin A1; Belongs to the cyclin family. | 0.936 |
CCNA2 | CDK2 | ENSGALP00000019361 | ENSGALP00000056613 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
CCNA2 | E2F1 | ENSGALP00000019361 | ENSGALP00000004806 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] | 0.995 |
CCNA2 | E2F2 | ENSGALP00000019361 | ENSGALP00000067798 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | E2F_TDP domain-containing protein. | 0.962 |
CCNA2 | E2F3 | ENSGALP00000019361 | ENSGALP00000036527 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | E2F transcription factor 3. | 0.963 |
CCNA2 | RB1 | ENSGALP00000019361 | ENSGALP00000071459 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] | 0.986 |
CCNA2 | RBL1 | ENSGALP00000019361 | ENSGALP00000069796 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | RB transcriptional corepressor like 1. | 0.769 |
CCNA2 | RBL2 | ENSGALP00000019361 | ENSGALP00000061242 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Uncharacterized protein. | 0.763 |
CCNA2 | TFDP1 | ENSGALP00000019361 | ENSGALP00000027109 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Transcription factor. | 0.657 |
CCNA2 | TFDP2 | ENSGALP00000019361 | ENSGALP00000055400 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Uncharacterized protein. | 0.583 |