node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | CCNA2 | ENSGALP00000027497 | ENSGALP00000019361 | Cyclin A1; Belongs to the cyclin family. | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | 0.936 |
CCNA1 | CDK2 | ENSGALP00000027497 | ENSGALP00000056613 | Cyclin A1; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
CCNA1 | E2F1 | ENSGALP00000027497 | ENSGALP00000004806 | Cyclin A1; Belongs to the cyclin family. | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] | 0.992 |
CCNA1 | FOXM1 | ENSGALP00000027497 | ENSGALP00000021851 | Cyclin A1; Belongs to the cyclin family. | Fork-head domain-containing protein. | 0.880 |
CCNA1 | MYBL2 | ENSGALP00000027497 | ENSGALP00000046271 | Cyclin A1; Belongs to the cyclin family. | Myb-related protein B; Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family. | 0.975 |
CCNA1 | NCAPH | ENSGALP00000027497 | ENSGALP00000073504 | Cyclin A1; Belongs to the cyclin family. | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | 0.642 |
CCNA2 | CCNA1 | ENSGALP00000019361 | ENSGALP00000027497 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Cyclin A1; Belongs to the cyclin family. | 0.936 |
CCNA2 | CDK2 | ENSGALP00000019361 | ENSGALP00000056613 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
CCNA2 | E2F1 | ENSGALP00000019361 | ENSGALP00000004806 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] | 0.995 |
CCNA2 | FOXM1 | ENSGALP00000019361 | ENSGALP00000021851 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Fork-head domain-containing protein. | 0.939 |
CCNA2 | MYBL2 | ENSGALP00000019361 | ENSGALP00000046271 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Myb-related protein B; Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family. | 0.976 |
CCNA2 | NCAPH | ENSGALP00000019361 | ENSGALP00000073504 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | 0.635 |
CDK2 | CCNA1 | ENSGALP00000056613 | ENSGALP00000027497 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Cyclin A1; Belongs to the cyclin family. | 0.999 |
CDK2 | CCNA2 | ENSGALP00000056613 | ENSGALP00000019361 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | 0.999 |
CDK2 | E2F1 | ENSGALP00000056613 | ENSGALP00000004806 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] | 0.981 |
CDK2 | FOXM1 | ENSGALP00000056613 | ENSGALP00000021851 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Fork-head domain-containing protein. | 0.755 |
CDK2 | MYBL2 | ENSGALP00000056613 | ENSGALP00000046271 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Myb-related protein B; Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family. | 0.959 |
E2F1 | CCNA1 | ENSGALP00000004806 | ENSGALP00000027497 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] | Cyclin A1; Belongs to the cyclin family. | 0.992 |
E2F1 | CCNA2 | ENSGALP00000004806 | ENSGALP00000019361 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | 0.995 |
E2F1 | CDK2 | ENSGALP00000004806 | ENSGALP00000056613 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.981 |