node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGRN | PTPRS | ENSGALP00000059759 | ENSGALP00000056093 | Agrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clu [...] | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] | 0.797 |
CASKIN2 | IL1RAPL1 | ENSGALP00000013016 | ENSGALP00000026211 | CASK interacting protein 2. | Interleukin 1 receptor accessory protein like 1. | 0.423 |
CASKIN2 | PTPRS | ENSGALP00000013016 | ENSGALP00000056093 | CASK interacting protein 2. | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] | 0.759 |
CASKIN2 | SLITRK1 | ENSGALP00000013016 | ENSGALP00000027275 | CASK interacting protein 2. | SLIT and NTRK like family member 1. | 0.428 |
IL1RAP | IL1RAPL1 | ENSGALP00000073766 | ENSGALP00000026211 | Interleukin 1 receptor accessory protein. | Interleukin 1 receptor accessory protein like 1. | 0.486 |
IL1RAP | NTRK3 | ENSGALP00000073766 | ENSGALP00000049680 | Interleukin 1 receptor accessory protein. | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | 0.453 |
IL1RAP | PTPRS | ENSGALP00000073766 | ENSGALP00000056093 | Interleukin 1 receptor accessory protein. | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] | 0.719 |
IL1RAP | SLITRK1 | ENSGALP00000073766 | ENSGALP00000027275 | Interleukin 1 receptor accessory protein. | SLIT and NTRK like family member 1. | 0.497 |
IL1RAP | SLITRK2 | ENSGALP00000073766 | ENSGALP00000014955 | Interleukin 1 receptor accessory protein. | SLIT and NTRK like family member 2. | 0.533 |
IL1RAPL1 | CASKIN2 | ENSGALP00000026211 | ENSGALP00000013016 | Interleukin 1 receptor accessory protein like 1. | CASK interacting protein 2. | 0.423 |
IL1RAPL1 | IL1RAP | ENSGALP00000026211 | ENSGALP00000073766 | Interleukin 1 receptor accessory protein like 1. | Interleukin 1 receptor accessory protein. | 0.486 |
IL1RAPL1 | NTRK3 | ENSGALP00000026211 | ENSGALP00000049680 | Interleukin 1 receptor accessory protein like 1. | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | 0.701 |
IL1RAPL1 | PTPRS | ENSGALP00000026211 | ENSGALP00000056093 | Interleukin 1 receptor accessory protein like 1. | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] | 0.893 |
IL1RAPL1 | SLITRK1 | ENSGALP00000026211 | ENSGALP00000027275 | Interleukin 1 receptor accessory protein like 1. | SLIT and NTRK like family member 1. | 0.812 |
IL1RAPL1 | SLITRK2 | ENSGALP00000026211 | ENSGALP00000014955 | Interleukin 1 receptor accessory protein like 1. | SLIT and NTRK like family member 2. | 0.758 |
IL1RAPL1 | SLITRK3 | ENSGALP00000026211 | ENSGALP00000053714 | Interleukin 1 receptor accessory protein like 1. | SLIT and NTRK like family member 3. | 0.777 |
NTRK3 | IL1RAP | ENSGALP00000049680 | ENSGALP00000073766 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | Interleukin 1 receptor accessory protein. | 0.453 |
NTRK3 | IL1RAPL1 | ENSGALP00000049680 | ENSGALP00000026211 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | Interleukin 1 receptor accessory protein like 1. | 0.701 |
NTRK3 | PTPRS | ENSGALP00000049680 | ENSGALP00000056093 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] | 0.997 |
NTRK3 | SLITRK1 | ENSGALP00000049680 | ENSGALP00000027275 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | SLIT and NTRK like family member 1. | 0.669 |