node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AACS | ACAA1 | ENSGALP00000004568 | ENSGALP00000009408 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.498 |
AACS | ACAA2 | ENSGALP00000004568 | ENSGALP00000053550 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.550 |
AACS | ACAT1 | ENSGALP00000004568 | ENSGALP00000027665 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.957 |
AACS | ACAT2 | ENSGALP00000004568 | ENSGALP00000019037 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.951 |
AACS | AUH | ENSGALP00000004568 | ENSGALP00000069282 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.414 |
AACS | BDH1A | ENSGALP00000004568 | ENSGALP00000011241 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.929 |
AACS | HMGCL | ENSGALP00000004568 | ENSGALP00000034301 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. | 0.948 |
AACS | HMGCS1 | ENSGALP00000004568 | ENSGALP00000049501 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. | 0.965 |
AACS | HMGCS2 | ENSGALP00000004568 | ENSGALP00000071170 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.945 |
AACS | OXCT1 | ENSGALP00000004568 | ENSGALP00000023917 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.922 |
ACAA1 | AACS | ENSGALP00000009408 | ENSGALP00000004568 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | 0.498 |
ACAA1 | ACAA2 | ENSGALP00000009408 | ENSGALP00000053550 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.924 |
ACAA1 | ACAT1 | ENSGALP00000009408 | ENSGALP00000027665 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.924 |
ACAA1 | ACAT2 | ENSGALP00000009408 | ENSGALP00000019037 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.918 |
ACAA1 | AUH | ENSGALP00000009408 | ENSGALP00000069282 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.751 |
ACAA1 | HMGCL | ENSGALP00000009408 | ENSGALP00000034301 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. | 0.967 |
ACAA1 | HMGCS1 | ENSGALP00000009408 | ENSGALP00000049501 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. | 0.986 |
ACAA1 | HMGCS2 | ENSGALP00000009408 | ENSGALP00000071170 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.985 |
ACAA1 | OXCT1 | ENSGALP00000009408 | ENSGALP00000023917 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.923 |
ACAA2 | AACS | ENSGALP00000053550 | ENSGALP00000004568 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). | 0.550 |