node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADA | ADAR | ENSGALP00000006620 | ENSGALP00000067956 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | RNA-specific Adenosine deaminase Transcript variant M. | 0.933 |
ADA | ADK | ENSGALP00000006620 | ENSGALP00000008095 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | PfkB domain-containing protein. | 0.994 |
ADA | CECR1 | ENSGALP00000006620 | ENSGALP00000072689 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | A_deaminase domain-containing protein. | 0.974 |
ADA | DCK | ENSGALP00000006620 | ENSGALP00000042484 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | dNK domain-containing protein. | 0.925 |
ADA | DPP4 | ENSGALP00000006620 | ENSGALP00000052897 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Uncharacterized protein; Belongs to the peptidase S9B family. | 0.980 |
ADA | EPHX2 | ENSGALP00000006620 | ENSGALP00000026689 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | AB hydrolase-1 domain-containing protein. | 0.916 |
ADA | NT5C2 | ENSGALP00000006620 | ENSGALP00000013294 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). | 0.932 |
ADA | NT5E | ENSGALP00000006620 | ENSGALP00000025482 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.958 |
ADA | NT5M | ENSGALP00000006620 | ENSGALP00000007716 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 5',3'-nucleotidase, mitochondrial. | 0.944 |
ADA | PNP | ENSGALP00000006620 | ENSGALP00000058946 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.983 |
ADAR | ADA | ENSGALP00000067956 | ENSGALP00000006620 | RNA-specific Adenosine deaminase Transcript variant M. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.933 |
ADK | ADA | ENSGALP00000008095 | ENSGALP00000006620 | PfkB domain-containing protein. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.994 |
ADK | CECR1 | ENSGALP00000008095 | ENSGALP00000072689 | PfkB domain-containing protein. | A_deaminase domain-containing protein. | 0.969 |
ADK | DCK | ENSGALP00000008095 | ENSGALP00000042484 | PfkB domain-containing protein. | dNK domain-containing protein. | 0.605 |
ADK | NT5C2 | ENSGALP00000008095 | ENSGALP00000013294 | PfkB domain-containing protein. | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). | 0.938 |
ADK | NT5E | ENSGALP00000008095 | ENSGALP00000025482 | PfkB domain-containing protein. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.952 |
ADK | NT5M | ENSGALP00000008095 | ENSGALP00000007716 | PfkB domain-containing protein. | 5',3'-nucleotidase, mitochondrial. | 0.902 |
ADK | PNP | ENSGALP00000008095 | ENSGALP00000058946 | PfkB domain-containing protein. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.984 |
CECR1 | ADA | ENSGALP00000072689 | ENSGALP00000006620 | A_deaminase domain-containing protein. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.974 |
CECR1 | ADK | ENSGALP00000072689 | ENSGALP00000008095 | A_deaminase domain-containing protein. | PfkB domain-containing protein. | 0.969 |