node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC42 | CLIP1 | ENSGALP00000065867 | ENSGALP00000067447 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] | CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. | 0.913 |
CDC42 | IQGAP1 | ENSGALP00000065867 | ENSGALP00000052786 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] | IQ motif containing GTPase activating protein 1. | 0.997 |
CENPE | CLASP1 | ENSGALP00000021544 | ENSGALP00000048670 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Cytoplasmic linker associated protein 1. | 0.544 |
CENPE | CLASP2 | ENSGALP00000021544 | ENSGALP00000068506 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Uncharacterized protein. | 0.696 |
CENPE | CLIP1 | ENSGALP00000021544 | ENSGALP00000067447 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. | 0.824 |
CENPE | DCTN1 | ENSGALP00000021544 | ENSGALP00000074144 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | 0.532 |
CENPE | MAPRE1 | ENSGALP00000021544 | ENSGALP00000010754 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Belongs to the MAPRE family. | 0.752 |
CENPE | NUDC | ENSGALP00000021544 | ENSGALP00000001315 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity). | 0.833 |
CENPE | PLK1 | ENSGALP00000021544 | ENSGALP00000009850 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Serine/threonine-protein kinase PLK. | 0.965 |
CLASP1 | CENPE | ENSGALP00000048670 | ENSGALP00000021544 | Cytoplasmic linker associated protein 1. | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.544 |
CLASP1 | CLIP1 | ENSGALP00000048670 | ENSGALP00000067447 | Cytoplasmic linker associated protein 1. | CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. | 0.861 |
CLASP1 | DCTN1 | ENSGALP00000048670 | ENSGALP00000074144 | Cytoplasmic linker associated protein 1. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | 0.575 |
CLASP1 | MAPRE1 | ENSGALP00000048670 | ENSGALP00000010754 | Cytoplasmic linker associated protein 1. | Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Belongs to the MAPRE family. | 0.537 |
CLASP1 | NUDC | ENSGALP00000048670 | ENSGALP00000001315 | Cytoplasmic linker associated protein 1. | Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity). | 0.859 |
CLASP1 | PLK1 | ENSGALP00000048670 | ENSGALP00000009850 | Cytoplasmic linker associated protein 1. | Serine/threonine-protein kinase PLK. | 0.862 |
CLASP2 | CENPE | ENSGALP00000068506 | ENSGALP00000021544 | Uncharacterized protein. | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.696 |
CLASP2 | CLIP1 | ENSGALP00000068506 | ENSGALP00000067447 | Uncharacterized protein. | CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. | 0.958 |
CLASP2 | DCTN1 | ENSGALP00000068506 | ENSGALP00000074144 | Uncharacterized protein. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | 0.476 |
CLASP2 | IQGAP1 | ENSGALP00000068506 | ENSGALP00000052786 | Uncharacterized protein. | IQ motif containing GTPase activating protein 1. | 0.501 |
CLASP2 | MAPRE1 | ENSGALP00000068506 | ENSGALP00000010754 | Uncharacterized protein. | Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Belongs to the MAPRE family. | 0.700 |