STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTDSPLCTD small phosphatase-like protein; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). (293 aa)    
Predicted Functional Partners:
PPP1R7
LRRcap domain-containing protein.
 
      0.898
CHST7
Sulfotransferase; Belongs to the sulfotransferase 1 family.
   
  
 0.742
B3GALT5
Hexosyltransferase.
      
 0.700
WT1
Uncharacterized protein.
    
 
 0.642
RCL1
RNA terminal phosphate cyclase like 1.
      
 0.601
BSPRY
B-box and SPRY domain containing.
      
 0.600
BZW1
Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly.
   
  
 0.596
R3HDM1
R3H domain containing 1.
      
 0.588
PRPF4B
Pre-mRNA processing factor 4B.
   
  
 0.585
EMC8
ER membrane protein complex subunit 8.
   
  
 0.584
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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