STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)    
Predicted Functional Partners:
TLR4
Toll-like receptor 4; Belongs to the Toll-like receptor family.
   
0.999
IRAK4
Protein kinase domain-containing protein.
   
 0.999
TLR2A
Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).
   
 0.999
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.999
TLR7
Toll-like receptor 7; Belongs to the Toll-like receptor family.
   
 0.998
TIRAP
TIR domain-containing protein.
   
 0.997
TLR5
TLR5; Belongs to the Toll-like receptor family.
   
 0.995
TLR3
Toll-like receptor 3; Belongs to the Toll-like receptor family.
   
 
 0.995
TLR2B
Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).
   
 
 0.995
IRF7
Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...]
   
 0.994
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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