STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SH3GLB1Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity). Belongs to the endophilin family. (387 aa)    
Predicted Functional Partners:
ODF2L
Outer dense fiber of sperm tails 2 like.
      
 0.908
UVRAG
C2 domain-containing protein.
   
 
 0.896
SH3GLB2
Endophilin-B2; Belongs to the endophilin family.
  
 
 
0.684
FARSB
B5 domain-containing protein.
   
  
 0.633
AMBRA1
Autophagy and beclin 1 regulator 1.
      
 0.627
BCAP29
Uncharacterized protein.
   
  
 0.606
USP14
Ubiquitin carboxyl-terminal hydrolase.
   
   0.600
BECN1
Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family.
   
 
 0.596
PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
    
 
 0.571
CLCA1
Chloride channel accessory 1.
 
    
 0.542
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (40%) [HD]