node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOA1 | APOA4 | ENSGALP00000011510 | ENSGALP00000071485 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | Uncharacterized protein. | 0.858 |
APOA1 | APOB | ENSGALP00000011510 | ENSGALP00000026550 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | 0.999 |
APOA1 | APOV1 | ENSGALP00000011510 | ENSGALP00000024373 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | Apovitellenin-1; Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes. | 0.879 |
APOA1 | CETP | ENSGALP00000011510 | ENSGALP00000001869 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). | 0.960 |
APOA1 | LCAT | ENSGALP00000011510 | ENSGALP00000043323 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | Phosphatidylcholine-sterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and influences cerebral spinal [...] | 0.990 |
APOA1 | LIPC | ENSGALP00000011510 | ENSGALP00000006724 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | Lipase C, hepatic type. | 0.824 |
APOA1 | VTG1 | ENSGALP00000011510 | ENSGALP00000044130 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | Lipovitellin-1; Precursor of the egg-yolk proteins that are sources of nutrients during early development of oviparous organisms. | 0.774 |
APOA1 | VTG2 | ENSGALP00000011510 | ENSGALP00000002888 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | Lipovitellin-1; Precursor of the major egg-yolk proteins that are sources of nutrients during early development of oviparous organisms. | 0.812 |
APOA4 | APOA1 | ENSGALP00000071485 | ENSGALP00000011510 | Uncharacterized protein. | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | 0.858 |
APOA4 | APOB | ENSGALP00000071485 | ENSGALP00000026550 | Uncharacterized protein. | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | 0.949 |
APOA4 | APOV1 | ENSGALP00000071485 | ENSGALP00000024373 | Uncharacterized protein. | Apovitellenin-1; Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes. | 0.627 |
APOA4 | CETP | ENSGALP00000071485 | ENSGALP00000001869 | Uncharacterized protein. | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). | 0.834 |
APOA4 | LCAT | ENSGALP00000071485 | ENSGALP00000043323 | Uncharacterized protein. | Phosphatidylcholine-sterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and influences cerebral spinal [...] | 0.754 |
APOA4 | LIPC | ENSGALP00000071485 | ENSGALP00000006724 | Uncharacterized protein. | Lipase C, hepatic type. | 0.750 |
APOA4 | MASP1 | ENSGALP00000071485 | ENSGALP00000011986 | Uncharacterized protein. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.633 |
APOA4 | SNX24 | ENSGALP00000071485 | ENSGALP00000029137 | Uncharacterized protein. | PX domain-containing protein. | 0.600 |
APOA4 | VTG1 | ENSGALP00000071485 | ENSGALP00000044130 | Uncharacterized protein. | Lipovitellin-1; Precursor of the egg-yolk proteins that are sources of nutrients during early development of oviparous organisms. | 0.656 |
APOA4 | VTG2 | ENSGALP00000071485 | ENSGALP00000002888 | Uncharacterized protein. | Lipovitellin-1; Precursor of the major egg-yolk proteins that are sources of nutrients during early development of oviparous organisms. | 0.644 |
APOB | APOA1 | ENSGALP00000026550 | ENSGALP00000011510 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. | 0.999 |
APOB | APOA4 | ENSGALP00000026550 | ENSGALP00000071485 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Uncharacterized protein. | 0.949 |