node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ITGA2 | ITGA3 | ENSGALP00000023991 | ENSGALP00000050801 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Uncharacterized protein; Belongs to the integrin alpha chain family. | 0.653 |
ITGA2 | ITGA4 | ENSGALP00000023991 | ENSGALP00000053380 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.630 |
ITGA2 | ITGA6 | ENSGALP00000023991 | ENSGALP00000056234 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. | 0.648 |
ITGA2 | ITGA7 | ENSGALP00000023991 | ENSGALP00000051585 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. | 0.565 |
ITGA2 | ITGA8 | ENSGALP00000023991 | ENSGALP00000065785 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.594 |
ITGA2 | ITGAV | ENSGALP00000023991 | ENSGALP00000047574 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.681 |
ITGA2 | ITGB1 | ENSGALP00000023991 | ENSGALP00000054354 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.957 |
ITGA2 | LAMC1 | ENSGALP00000023991 | ENSGALP00000038625 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Laminin subunit gamma 1. | 0.732 |
ITGA2 | PELO | ENSGALP00000023991 | ENSGALP00000023976 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | 0.613 |
ITGA2 | PTK2 | ENSGALP00000023991 | ENSGALP00000071114 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous s [...] | 0.730 |
ITGA3 | ITGA2 | ENSGALP00000050801 | ENSGALP00000023991 | Uncharacterized protein; Belongs to the integrin alpha chain family. | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | 0.653 |
ITGA3 | ITGA4 | ENSGALP00000050801 | ENSGALP00000053380 | Uncharacterized protein; Belongs to the integrin alpha chain family. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.645 |
ITGA3 | ITGA6 | ENSGALP00000050801 | ENSGALP00000056234 | Uncharacterized protein; Belongs to the integrin alpha chain family. | Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. | 0.628 |
ITGA3 | ITGA7 | ENSGALP00000050801 | ENSGALP00000051585 | Uncharacterized protein; Belongs to the integrin alpha chain family. | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. | 0.620 |
ITGA3 | ITGA8 | ENSGALP00000050801 | ENSGALP00000065785 | Uncharacterized protein; Belongs to the integrin alpha chain family. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.642 |
ITGA3 | ITGAV | ENSGALP00000050801 | ENSGALP00000047574 | Uncharacterized protein; Belongs to the integrin alpha chain family. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.664 |
ITGA3 | ITGB1 | ENSGALP00000050801 | ENSGALP00000054354 | Uncharacterized protein; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.956 |
ITGA3 | PELO | ENSGALP00000050801 | ENSGALP00000023976 | Uncharacterized protein; Belongs to the integrin alpha chain family. | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | 0.676 |
ITGA3 | PTK2 | ENSGALP00000050801 | ENSGALP00000071114 | Uncharacterized protein; Belongs to the integrin alpha chain family. | Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous s [...] | 0.588 |
ITGA4 | ITGA2 | ENSGALP00000053380 | ENSGALP00000023991 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | 0.630 |