STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NEFHNeurofilament heavy; Belongs to the intermediate filament family. (947 aa)    
Predicted Functional Partners:
NEFL
Neurofilament light; Belongs to the intermediate filament family.
   
 
0.821
INA
Internexin neuronal intermediate filament protein alpha; Belongs to the intermediate filament family.
   
  
0.587
CALB1
Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
   
 
 0.543
NR2E1
Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation (By similarity). Involved in the regulation of retinal development; Belongs to the nuclear hormone receptor family. NR2 subfamily.
   
 
 0.524
CALB2
Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons.
   
 
 0.509
GAP43
Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
   
  
 0.484
SNCG
Gamma-synuclein; Belongs to the synuclein family.
   
  
 0.454
C9orf72
C9orf72-SMCR8 complex subunit.
      
 0.446
ALS2
Alsin Rho guanine nucleotide exchange factor ALS2.
    
 
 0.421
TARDBP
TAR DNA-binding protein 43; Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity (By similarity).
   
 
 0.406
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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