node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC6 | CDT1 | ENSGALP00000067395 | ENSGALP00000022344 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
CDC6 | MCM2 | ENSGALP00000067395 | ENSGALP00000009709 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC6 | MCM3 | ENSGALP00000067395 | ENSGALP00000026858 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
CDC6 | MCM5 | ENSGALP00000067395 | ENSGALP00000020463 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC6 | ORC1 | ENSGALP00000067395 | ENSGALP00000017266 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
CDC6 | ORC2 | ENSGALP00000067395 | ENSGALP00000013386 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Uncharacterized protein. | 0.999 |
CDC6 | ORC3 | ENSGALP00000067395 | ENSGALP00000025431 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | ORC_WH_C domain-containing protein. | 0.999 |
CDC6 | ORC4 | ENSGALP00000067395 | ENSGALP00000020323 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.999 |
CDC6 | ORC5 | ENSGALP00000067395 | ENSGALP00000074081 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | AAA_16 domain-containing protein. | 0.999 |
CDC6 | ORC6 | ENSGALP00000067395 | ENSGALP00000049556 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Uncharacterized protein. | 0.997 |
CDT1 | CDC6 | ENSGALP00000022344 | ENSGALP00000067395 | Chromatin licensing and DNA replication factor 1. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.999 |
CDT1 | MCM2 | ENSGALP00000022344 | ENSGALP00000009709 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.998 |
CDT1 | MCM3 | ENSGALP00000022344 | ENSGALP00000026858 | Chromatin licensing and DNA replication factor 1. | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
CDT1 | MCM5 | ENSGALP00000022344 | ENSGALP00000020463 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDT1 | ORC1 | ENSGALP00000022344 | ENSGALP00000017266 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
CDT1 | ORC2 | ENSGALP00000022344 | ENSGALP00000013386 | Chromatin licensing and DNA replication factor 1. | Uncharacterized protein. | 0.998 |
CDT1 | ORC3 | ENSGALP00000022344 | ENSGALP00000025431 | Chromatin licensing and DNA replication factor 1. | ORC_WH_C domain-containing protein. | 0.998 |
CDT1 | ORC4 | ENSGALP00000022344 | ENSGALP00000020323 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.999 |
CDT1 | ORC5 | ENSGALP00000022344 | ENSGALP00000074081 | Chromatin licensing and DNA replication factor 1. | AAA_16 domain-containing protein. | 0.999 |
CDT1 | ORC6 | ENSGALP00000022344 | ENSGALP00000049556 | Chromatin licensing and DNA replication factor 1. | Uncharacterized protein. | 0.990 |