node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADA | ADK | ENSGALP00000006620 | ENSGALP00000008095 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | PfkB domain-containing protein. | 0.994 |
ADA | CECR1 | ENSGALP00000006620 | ENSGALP00000072689 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | A_deaminase domain-containing protein. | 0.974 |
ADA | DCK | ENSGALP00000006620 | ENSGALP00000042484 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | dNK domain-containing protein. | 0.925 |
ADA | HPRT1 | ENSGALP00000006620 | ENSGALP00000009829 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | 0.543 |
ADA | IMPDH2 | ENSGALP00000006620 | ENSGALP00000055868 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.604 |
ADA | NT5C2 | ENSGALP00000006620 | ENSGALP00000013294 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). | 0.932 |
ADA | NT5M | ENSGALP00000006620 | ENSGALP00000007716 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 5',3'-nucleotidase, mitochondrial. | 0.944 |
ADA | PNP | ENSGALP00000006620 | ENSGALP00000058946 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.983 |
ADK | ADA | ENSGALP00000008095 | ENSGALP00000006620 | PfkB domain-containing protein. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.994 |
ADK | CECR1 | ENSGALP00000008095 | ENSGALP00000072689 | PfkB domain-containing protein. | A_deaminase domain-containing protein. | 0.969 |
ADK | DCK | ENSGALP00000008095 | ENSGALP00000042484 | PfkB domain-containing protein. | dNK domain-containing protein. | 0.605 |
ADK | DCTD | ENSGALP00000008095 | ENSGALP00000017346 | PfkB domain-containing protein. | CMP/dCMP-type deaminase domain-containing protein. | 0.414 |
ADK | HPRT1 | ENSGALP00000008095 | ENSGALP00000009829 | PfkB domain-containing protein. | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | 0.420 |
ADK | IMPDH2 | ENSGALP00000008095 | ENSGALP00000055868 | PfkB domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.428 |
ADK | NT5C2 | ENSGALP00000008095 | ENSGALP00000013294 | PfkB domain-containing protein. | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). | 0.938 |
ADK | NT5M | ENSGALP00000008095 | ENSGALP00000007716 | PfkB domain-containing protein. | 5',3'-nucleotidase, mitochondrial. | 0.902 |
ADK | PNP | ENSGALP00000008095 | ENSGALP00000058946 | PfkB domain-containing protein. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.984 |
CECR1 | ADA | ENSGALP00000072689 | ENSGALP00000006620 | A_deaminase domain-containing protein. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.974 |
CECR1 | ADK | ENSGALP00000072689 | ENSGALP00000008095 | A_deaminase domain-containing protein. | PfkB domain-containing protein. | 0.969 |
CECR1 | DCK | ENSGALP00000072689 | ENSGALP00000042484 | A_deaminase domain-containing protein. | dNK domain-containing protein. | 0.900 |