STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MDKMidkine; Has mitogenic activity, and neurite extension activity for PC12 cells; Belongs to the pleiotrophin family. (239 aa)    
Predicted Functional Partners:
ALK
Tyrosine-protein kinase receptor.
    
 0.976
PTPRZ1
Protein-tyrosine-phosphatase.
    
 0.903
HDGF
Heparin binding growth factor.
      
 0.783
NCL
Nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly.
    
 
 0.740
LTK
Tyrosine-protein kinase receptor.
    
 
 0.717
STAT3
Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.
     
 0.658
PTN
Pleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity); Belongs to the pleiotrophin family.
   
0.642
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
     
 0.627
ZHX2
Zinc fingers and homeoboxes 2.
      
 0.627
REM1
RRAD and GEM like GTPase 1.
      
 0.627
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.