node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP4 | DLX5 | ENSGALP00000020289 | ENSGALP00000014846 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | 0.711 |
BMP4 | DLX6 | ENSGALP00000020289 | ENSGALP00000069962 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Homeobox domain-containing protein. | 0.445 |
BMP4 | EYA1 | ENSGALP00000020289 | ENSGALP00000051963 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] | 0.629 |
BMP4 | FOXG1 | ENSGALP00000020289 | ENSGALP00000054672 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. | 0.620 |
BMP4 | PAX2 | ENSGALP00000020289 | ENSGALP00000045193 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Paired-box containing protein Pax-2. | 0.708 |
BMP4 | RUNX2 | ENSGALP00000020289 | ENSGALP00000050655 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Runt-related transcription factor. | 0.739 |
BMP4 | SIX1 | ENSGALP00000020289 | ENSGALP00000046244 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Sine oculis-related homeobox 1 homolog. | 0.653 |
BMP4 | SOX9 | ENSGALP00000020289 | ENSGALP00000037718 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] | 0.847 |
BMP4 | TFAP2A | ENSGALP00000020289 | ENSGALP00000020815 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | TF_AP-2 domain-containing protein. | 0.522 |
DLX5 | BMP4 | ENSGALP00000014846 | ENSGALP00000020289 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | 0.711 |
DLX5 | DLX6 | ENSGALP00000014846 | ENSGALP00000069962 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | Homeobox domain-containing protein. | 0.752 |
DLX5 | EYA1 | ENSGALP00000014846 | ENSGALP00000051963 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] | 0.721 |
DLX5 | FOXG1 | ENSGALP00000014846 | ENSGALP00000054672 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. | 0.724 |
DLX5 | LHX6 | ENSGALP00000014846 | ENSGALP00000044370 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | LIM homeobox 6. | 0.766 |
DLX5 | PAX2 | ENSGALP00000014846 | ENSGALP00000045193 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | Paired-box containing protein Pax-2. | 0.710 |
DLX5 | RUNX2 | ENSGALP00000014846 | ENSGALP00000050655 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | Runt-related transcription factor. | 0.790 |
DLX5 | SIX1 | ENSGALP00000014846 | ENSGALP00000046244 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | Sine oculis-related homeobox 1 homolog. | 0.784 |
DLX5 | SOX9 | ENSGALP00000014846 | ENSGALP00000037718 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] | 0.711 |
DLX5 | TFAP2A | ENSGALP00000014846 | ENSGALP00000020815 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. | TF_AP-2 domain-containing protein. | 0.702 |
DLX6 | BMP4 | ENSGALP00000069962 | ENSGALP00000020289 | Homeobox domain-containing protein. | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | 0.445 |