STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ASB2Ankyrin repeat and SOCS box containing 2. (645 aa)    
Predicted Functional Partners:
CUL5
Cullin 5; Belongs to the cullin family.
    
 0.898
COL20A1
Uncharacterized protein.
   
 
 0.726
ASB12
ANK_REP_REGION domain-containing protein.
  
 
0.726
RNF7
RING-type domain-containing protein.
    
 0.722
USP45
Ubiquitin carboxyl-terminal hydrolase.
   
  
 0.705
FAM181A
Family with sequence similarity 181 member A.
      
 0.704
CISH
Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]
   
 
 0.703
TCEB1
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
    
 0.687
VWA1
Von Willebrand factor A domain containing 1.
   
 
 0.657
ANKRD1
Ankyrin repeat domain-containing protein 1; May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
  
 
0.594
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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