node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARNT2 | THRA | ENSGALP00000052707 | ENSGALP00000070264 | Aryl hydrocarbon receptor nuclear translocator 2. | Thyroid hormone receptor alpha. | 0.413 |
ARNT2 | THRB | ENSGALP00000052707 | ENSGALP00000018402 | Aryl hydrocarbon receptor nuclear translocator 2. | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.587 |
DIO2 | SLC16A2 | ENSGALP00000068702 | ENSGALP00000012547 | Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. | Uncharacterized protein. | 0.714 |
DIO2 | THRA | ENSGALP00000068702 | ENSGALP00000070264 | Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. | Thyroid hormone receptor alpha. | 0.484 |
DIO2 | THRB | ENSGALP00000068702 | ENSGALP00000018402 | Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.664 |
DIO2 | TSHB-2 | ENSGALP00000068702 | ENSGALP00000004015 | Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.741 |
MED1 | NCOR2 | ENSGALP00000002620 | ENSGALP00000073350 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 2. | 0.564 |
MED1 | RXRA | ENSGALP00000002620 | ENSGALP00000046810 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoid X receptor alpha. | 0.764 |
MED1 | RXRG | ENSGALP00000002620 | ENSGALP00000068361 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). | 0.763 |
MED1 | THRA | ENSGALP00000002620 | ENSGALP00000070264 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Thyroid hormone receptor alpha. | 0.661 |
MED1 | THRB | ENSGALP00000002620 | ENSGALP00000018402 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.661 |
NCOR2 | MED1 | ENSGALP00000073350 | ENSGALP00000002620 | Nuclear receptor corepressor 2. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.564 |
NCOR2 | RXRA | ENSGALP00000073350 | ENSGALP00000046810 | Nuclear receptor corepressor 2. | Retinoid X receptor alpha. | 0.788 |
NCOR2 | RXRG | ENSGALP00000073350 | ENSGALP00000068361 | Nuclear receptor corepressor 2. | Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). | 0.788 |
NCOR2 | THRA | ENSGALP00000073350 | ENSGALP00000070264 | Nuclear receptor corepressor 2. | Thyroid hormone receptor alpha. | 0.695 |
NCOR2 | THRB | ENSGALP00000073350 | ENSGALP00000018402 | Nuclear receptor corepressor 2. | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.683 |
ONECUT1 | THRB | ENSGALP00000045331 | ENSGALP00000018402 | One cut domain family member. | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.604 |
RXRA | MED1 | ENSGALP00000046810 | ENSGALP00000002620 | Retinoid X receptor alpha. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.764 |
RXRA | NCOR2 | ENSGALP00000046810 | ENSGALP00000073350 | Retinoid X receptor alpha. | Nuclear receptor corepressor 2. | 0.788 |
RXRA | RXRG | ENSGALP00000046810 | ENSGALP00000068361 | Retinoid X receptor alpha. | Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). | 0.903 |