node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IGF1 | IGF1R | ENSGALP00000020787 | ENSGALP00000056946 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | Tyrosine-protein kinase receptor. | 0.961 |
IGF1 | IGF2 | ENSGALP00000020787 | ENSGALP00000048743 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. | 0.473 |
IGF1 | IGFBP1 | ENSGALP00000020787 | ENSGALP00000055736 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | Uncharacterized protein. | 0.816 |
IGF1 | IGFBP2 | ENSGALP00000020787 | ENSGALP00000018675 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. | 0.790 |
IGF1 | IGFBP3 | ENSGALP00000020787 | ENSGALP00000055577 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | Uncharacterized protein. | 0.930 |
IGF1 | INS | ENSGALP00000020787 | ENSGALP00000010567 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.944 |
IGF1R | IGF1 | ENSGALP00000056946 | ENSGALP00000020787 | Tyrosine-protein kinase receptor. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | 0.961 |
IGF1R | IGF2 | ENSGALP00000056946 | ENSGALP00000048743 | Tyrosine-protein kinase receptor. | Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. | 0.997 |
IGF1R | IGF2R | ENSGALP00000056946 | ENSGALP00000048816 | Tyrosine-protein kinase receptor. | Fibronectin type-II domain-containing protein. | 0.813 |
IGF1R | IGFBP1 | ENSGALP00000056946 | ENSGALP00000055736 | Tyrosine-protein kinase receptor. | Uncharacterized protein. | 0.590 |
IGF1R | IGFBP2 | ENSGALP00000056946 | ENSGALP00000018675 | Tyrosine-protein kinase receptor. | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. | 0.610 |
IGF1R | IGFBP3 | ENSGALP00000056946 | ENSGALP00000055577 | Tyrosine-protein kinase receptor. | Uncharacterized protein. | 0.596 |
IGF1R | INS | ENSGALP00000056946 | ENSGALP00000010567 | Tyrosine-protein kinase receptor. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.996 |
IGF1R | PPARG | ENSGALP00000056946 | ENSGALP00000067699 | Tyrosine-protein kinase receptor. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.414 |
IGF2 | IGF1 | ENSGALP00000048743 | ENSGALP00000020787 | Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | 0.473 |
IGF2 | IGF1R | ENSGALP00000048743 | ENSGALP00000056946 | Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. | Tyrosine-protein kinase receptor. | 0.997 |
IGF2 | IGF2R | ENSGALP00000048743 | ENSGALP00000048816 | Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. | Fibronectin type-II domain-containing protein. | 0.998 |
IGF2 | IGFALS | ENSGALP00000048743 | ENSGALP00000038622 | Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. | Insulin like growth factor binding protein acid labile subunit. | 0.453 |
IGF2 | IGFBP1 | ENSGALP00000048743 | ENSGALP00000055736 | Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. | Uncharacterized protein. | 0.962 |
IGF2 | IGFBP2 | ENSGALP00000048743 | ENSGALP00000018675 | Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. | 0.984 |