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SERPINB10 protein (Gallus gallus) - STRING interaction network
"SERPINB10" - Heterochromatin-associated protein MENT in Gallus gallus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SERPINB10Heterochromatin-associated protein MENT; DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells. Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization. Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases; Belongs to the serpin family. Ov-serpin subfamily (410 aa)    
Predicted Functional Partners:
S100A9
Protein MRP-126 (119 aa)
     
   
  0.858
ENSGALG00000026020
Histone H5; Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells (190 aa)
       
 
  0.743
H1F0
Histone H5; Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells (190 aa)
       
 
  0.743
GAL2
Gallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans (64 aa)
     
   
  0.737
RSFR
Gallus gallus leukocyte ribonuclease A-2 (RSFR), mRNA (139 aa)
     
   
  0.727
LECT2
Myeloid protein 1; Gallus gallus leukocyte cell-derived chemotaxin 2 (LECT2), mRNA (322 aa)
     
   
  0.689
C3H6ORF174
Uncharacterized protein (700 aa)
           
  0.681
RGPD1
Uncharacterized protein (816 aa)
           
  0.681
CAMP
Cathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response (154 aa)
     
   
  0.634
LCN8
Extracellular fatty acid-binding protein; Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor; Belongs to the calycin superfamily. Lipocalin family (178 aa)
           
  0.628
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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