STRINGSTRING
SERPINB10 protein (Gallus gallus) - STRING interaction network
"SERPINB10" - Heterochromatin-associated protein MENT in Gallus gallus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINB10Heterochromatin-associated protein MENT ; DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells. Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization. Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases (410 aa)    
Predicted Functional Partners:
C10ORF112
Uncharacterized protein (348 aa)
           
  0.676
PNPLA6
Neuropathy target esterase (1070 aa)
         
  0.659
F2
Prothrombin precursor ; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (607 aa)
   
  0.566
HABP2
Uncharacterized protein (492 aa)
   
  0.529
HGFAC
Uncharacterized protein (569 aa)
   
  0.529
PLAU
Urokinase-type plasminogen activator preproprotein ; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin (434 aa)
     
  0.476
HGF
Hepatocyte growth factor precursor ; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (726 aa)
   
  0.453
PLG
Uncharacterized protein ; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may b [...] (815 aa)
   
  0.453
MST1
Hepatocyte growth factor-like protein precursor (664 aa)
   
  0.453
CFI
Uncharacterized protein (543 aa)
   
  0.447
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, Phasianinae, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (15%) [HD]