node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEBP2 | BMI1 | ENSGALP00000054126 | ENSGALP00000051910 | AE binding protein 2. | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. | 0.639 |
AEBP2 | EED | ENSGALP00000054126 | ENSGALP00000057840 | AE binding protein 2. | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). | 0.995 |
AEBP2 | EZH1 | ENSGALP00000054126 | ENSGALP00000056397 | AE binding protein 2. | Enhancer of zeste 1 polycomb repressive complex 2 subunit. | 0.971 |
AEBP2 | EZH2 | ENSGALP00000054126 | ENSGALP00000054289 | AE binding protein 2. | Enhancer of zeste 2 polycomb repressive complex 2 subunit. | 0.970 |
AEBP2 | JARID2 | ENSGALP00000054126 | ENSGALP00000020711 | AE binding protein 2. | Protein Jumonji; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone [...] | 0.998 |
AEBP2 | MTF2 | ENSGALP00000054126 | ENSGALP00000047838 | AE binding protein 2. | PHD-type domain-containing protein. | 0.768 |
AEBP2 | PHF19 | ENSGALP00000054126 | ENSGALP00000002418 | AE binding protein 2. | PHD finger protein 19. | 0.859 |
AEBP2 | RBBP4 | ENSGALP00000054126 | ENSGALP00000005565 | AE binding protein 2. | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. | 0.984 |
AEBP2 | RBBP7 | ENSGALP00000054126 | ENSGALP00000026647 | AE binding protein 2. | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. | 0.952 |
AEBP2 | RNF2 | ENSGALP00000054126 | ENSGALP00000069071 | AE binding protein 2. | Ring finger protein 2. | 0.631 |
BMI1 | AEBP2 | ENSGALP00000051910 | ENSGALP00000054126 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. | AE binding protein 2. | 0.639 |
BMI1 | EED | ENSGALP00000051910 | ENSGALP00000057840 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). | 0.907 |
BMI1 | EZH1 | ENSGALP00000051910 | ENSGALP00000056397 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. | Enhancer of zeste 1 polycomb repressive complex 2 subunit. | 0.720 |
BMI1 | EZH2 | ENSGALP00000051910 | ENSGALP00000054289 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. | Enhancer of zeste 2 polycomb repressive complex 2 subunit. | 0.918 |
BMI1 | RBBP4 | ENSGALP00000051910 | ENSGALP00000005565 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. | 0.791 |
BMI1 | RBBP7 | ENSGALP00000051910 | ENSGALP00000026647 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. | 0.794 |
BMI1 | RNF2 | ENSGALP00000051910 | ENSGALP00000069071 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. | Ring finger protein 2. | 0.983 |
EED | AEBP2 | ENSGALP00000057840 | ENSGALP00000054126 | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). | AE binding protein 2. | 0.995 |
EED | BMI1 | ENSGALP00000057840 | ENSGALP00000051910 | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. | 0.907 |
EED | EZH1 | ENSGALP00000057840 | ENSGALP00000056397 | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). | Enhancer of zeste 1 polycomb repressive complex 2 subunit. | 0.993 |