node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GH | GHR | ENSGALP00000000327 | ENSGALP00000046304 | Somatotropin; Growth hormone plays an important role in growth control. | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | 0.994 |
GH | GHRL | ENSGALP00000000327 | ENSGALP00000013685 | Somatotropin; Growth hormone plays an important role in growth control. | Preproghrelin. | 0.953 |
GH | IGF1 | ENSGALP00000000327 | ENSGALP00000020787 | Somatotropin; Growth hormone plays an important role in growth control. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | 0.704 |
GH | JAK2 | ENSGALP00000000327 | ENSGALP00000074116 | Somatotropin; Growth hormone plays an important role in growth control. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] | 0.681 |
GH | LOC417800 | ENSGALP00000000327 | ENSGALP00000015633 | Somatotropin; Growth hormone plays an important role in growth control. | Uncharacterized protein. | 0.463 |
GH | PRL | ENSGALP00000000327 | ENSGALP00000020651 | Somatotropin; Growth hormone plays an important role in growth control. | Prolactin. | 0.924 |
GH | SST | ENSGALP00000000327 | ENSGALP00000011889 | Somatotropin; Growth hormone plays an important role in growth control. | Somatostatin-14; Somatostatin inhibits the release of somatotropin. | 0.559 |
GH | STAT5A | ENSGALP00000000327 | ENSGALP00000005182 | Somatotropin; Growth hormone plays an important role in growth control. | Signal transducer and activator of transcription. | 0.632 |
GHR | GH | ENSGALP00000046304 | ENSGALP00000000327 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Somatotropin; Growth hormone plays an important role in growth control. | 0.994 |
GHR | GHRL | ENSGALP00000046304 | ENSGALP00000013685 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Preproghrelin. | 0.648 |
GHR | IGF1 | ENSGALP00000046304 | ENSGALP00000020787 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] | 0.630 |
GHR | JAK2 | ENSGALP00000046304 | ENSGALP00000074116 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] | 0.986 |
GHR | LOC417800 | ENSGALP00000046304 | ENSGALP00000015633 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Uncharacterized protein. | 0.785 |
GHR | PRL | ENSGALP00000046304 | ENSGALP00000020651 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Prolactin. | 0.895 |
GHR | SOCS2 | ENSGALP00000046304 | ENSGALP00000067577 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Uncharacterized protein. | 0.891 |
GHR | SPP2 | ENSGALP00000046304 | ENSGALP00000044476 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Secreted phosphoprotein 24; Could coordinate an aspect of bone turnover. | 0.715 |
GHR | SST | ENSGALP00000046304 | ENSGALP00000011889 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Somatostatin-14; Somatostatin inhibits the release of somatotropin. | 0.688 |
GHR | STAT5A | ENSGALP00000046304 | ENSGALP00000005182 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | Signal transducer and activator of transcription. | 0.869 |
GHRL | GH | ENSGALP00000013685 | ENSGALP00000000327 | Preproghrelin. | Somatotropin; Growth hormone plays an important role in growth control. | 0.953 |
GHRL | GHR | ENSGALP00000013685 | ENSGALP00000046304 | Preproghrelin. | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. | 0.648 |