node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP4 | EGF | ENSGALP00000020289 | ENSGALP00000044972 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Uncharacterized protein. | 0.751 |
BMP4 | FGF10 | ENSGALP00000020289 | ENSGALP00000065453 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Uncharacterized protein. | 0.921 |
BMP4 | FGF2 | ENSGALP00000020289 | ENSGALP00000031519 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | 0.861 |
BMP4 | FGF8 | ENSGALP00000020289 | ENSGALP00000032574 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. | 0.874 |
BMP4 | FGFR1 | ENSGALP00000020289 | ENSGALP00000046610 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers re [...] | 0.689 |
BMP4 | FGFR2 | ENSGALP00000020289 | ENSGALP00000045192 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.651 |
BMP4 | FGFR3 | ENSGALP00000020289 | ENSGALP00000001710 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] | 0.562 |
BMP4 | PDGFRA | ENSGALP00000020289 | ENSGALP00000064586 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound he [...] | 0.685 |
BMP4 | SHH | ENSGALP00000020289 | ENSGALP00000010292 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.964 |
EGF | BMP4 | ENSGALP00000044972 | ENSGALP00000020289 | Uncharacterized protein. | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | 0.751 |
EGF | FGF10 | ENSGALP00000044972 | ENSGALP00000065453 | Uncharacterized protein. | Uncharacterized protein. | 0.926 |
EGF | FGF2 | ENSGALP00000044972 | ENSGALP00000031519 | Uncharacterized protein. | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | 0.986 |
EGF | FGF8 | ENSGALP00000044972 | ENSGALP00000032574 | Uncharacterized protein. | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. | 0.953 |
EGF | FGFR1 | ENSGALP00000044972 | ENSGALP00000046610 | Uncharacterized protein. | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers re [...] | 0.862 |
EGF | FGFR2 | ENSGALP00000044972 | ENSGALP00000045192 | Uncharacterized protein. | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.818 |
EGF | FGFR3 | ENSGALP00000044972 | ENSGALP00000001710 | Uncharacterized protein. | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] | 0.816 |
EGF | FGFR4 | ENSGALP00000044972 | ENSGALP00000025286 | Uncharacterized protein. | Fibroblast growth factor receptor. | 0.782 |
EGF | PDGFRA | ENSGALP00000044972 | ENSGALP00000064586 | Uncharacterized protein. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound he [...] | 0.974 |
EGF | SHH | ENSGALP00000044972 | ENSGALP00000010292 | Uncharacterized protein. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.745 |
FGF10 | BMP4 | ENSGALP00000065453 | ENSGALP00000020289 | Uncharacterized protein. | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. | 0.921 |