STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ESCO1Establishment of sister chromatid cohesion N-acetyltransferase 1. (856 aa)    
Predicted Functional Partners:
SMC3
Structural maintenance of chromosomes protein.
   
 0.982
WAPL
WAPL domain-containing protein.
   
 
 0.928
PDS5A
Sister chromatid cohesion protein PDS5 homolog A; May regulate sister chromatid cohesion during mitosis and couple it to DNA replication.
   
 0.916
PDS5B
Sister chromatid cohesion protein PDS5 homolog B; Plays a role in androgen-induced proliferative arrest. Required for maintenance of sister chromatid cohesion during mitosis (By similarity).
   
 0.839
AANAT
Serotonin N-acetyltransferase; Catalyzes the N-acetylation of serotonin into N- acetylserotonin; Belongs to the acetyltransferase family. AANAT subfamily.
   
  
 0.819
RAD21
Uncharacterized protein.
   
 0.800
ASMT
Acetylserotonin O-methyltransferase; Catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
      
 0.788
DDX11
DEAD/H-box helicase 11.
   
 
 0.782
SMC5
Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...]
   
 
 0.756
NAT8B
N-acetyltransferase domain-containing protein.
      
 0.740
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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