STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MX1Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus (705 aa)    
Predicted Functional Partners:
OASL
Gallus gallus 2'-5'-oligoadenylate synthetase-like (OASL), mRNA
   
 
 0.999
IFIT5
Uncharacterized protein
   
  
 0.973
ISG12-2
Putative ISG12(2) protein; Gallus gallus ISG12-2 protein-like (ISG12-2), mRNA
   
  
 0.959
RSAD2
Radical S-adenosyl methionine domain containing 2; Uncharacterized protein; Viperin
   
  
 0.959
USP18
Uncharacterized protein; Ubiquitin carboxyl-terminal hydrolase ; Belongs to the peptidase C19 family
   
 
 0.948
TLR3
Gallus gallus toll-like receptor 3 (TLR3), mRNA
   
 
 0.932
IRF7
Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the I [...]
   
  
 0.926
CMPK2
Uncharacterized protein; Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
   
  
 0.894
IFIH1
Uncharacterized protein; Gallus gallus interferon induced with helicase C domain 1 (IFIH1), mRNA
   
  
 0.864
STAT1
Gallus gallus signal transducer and activator of transcription 1, 91kDa (STAT1), mRNA
   
  
 0.863
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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