node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DESI1 | SUMO2 | ENSGALP00000073779 | ENSGALP00000012928 | Desumoylating isopeptidase 1. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | 0.674 |
DESI1 | USPL1 | ENSGALP00000073779 | ENSGALP00000027538 | Desumoylating isopeptidase 1. | USP domain-containing protein. | 0.875 |
DESI2 | SUMO2 | ENSGALP00000017350 | ENSGALP00000012928 | Deubiquitinase DESI2; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | 0.577 |
DESI2 | USPL1 | ENSGALP00000017350 | ENSGALP00000027538 | Deubiquitinase DESI2; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. | USP domain-containing protein. | 0.784 |
ICE2 | NWD1 | ENSGALP00000071500 | ENSGALP00000040424 | Interactor of little elongation complex ELL subunit 2. | WD_REPEATS_REGION domain-containing protein. | 0.569 |
ICE2 | PRPF6 | ENSGALP00000071500 | ENSGALP00000009642 | Interactor of little elongation complex ELL subunit 2. | Pre-mRNA processing factor 6. | 0.601 |
ICE2 | USPL1 | ENSGALP00000071500 | ENSGALP00000027538 | Interactor of little elongation complex ELL subunit 2. | USP domain-containing protein. | 0.856 |
NWD1 | ICE2 | ENSGALP00000040424 | ENSGALP00000071500 | WD_REPEATS_REGION domain-containing protein. | Interactor of little elongation complex ELL subunit 2. | 0.569 |
NWD1 | PRPF6 | ENSGALP00000040424 | ENSGALP00000009642 | WD_REPEATS_REGION domain-containing protein. | Pre-mRNA processing factor 6. | 0.999 |
NWD1 | USPL1 | ENSGALP00000040424 | ENSGALP00000027538 | WD_REPEATS_REGION domain-containing protein. | USP domain-containing protein. | 0.695 |
PAN2 | USP50 | ENSGALP00000056405 | ENSGALP00000071295 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] | UCH domain-containing protein. | 0.955 |
PAN2 | USP54 | ENSGALP00000056405 | ENSGALP00000008393 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] | Ubiquitin specific peptidase 54. | 0.843 |
PAN2 | USPL1 | ENSGALP00000056405 | ENSGALP00000027538 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] | USP domain-containing protein. | 0.842 |
PRPF6 | ICE2 | ENSGALP00000009642 | ENSGALP00000071500 | Pre-mRNA processing factor 6. | Interactor of little elongation complex ELL subunit 2. | 0.601 |
PRPF6 | NWD1 | ENSGALP00000009642 | ENSGALP00000040424 | Pre-mRNA processing factor 6. | WD_REPEATS_REGION domain-containing protein. | 0.999 |
PRPF6 | USPL1 | ENSGALP00000009642 | ENSGALP00000027538 | Pre-mRNA processing factor 6. | USP domain-containing protein. | 0.707 |
SENP5 | SUMO2 | ENSGALP00000052202 | ENSGALP00000012928 | SUMO specific peptidase 5. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | 0.930 |
SENP5 | USPL1 | ENSGALP00000052202 | ENSGALP00000027538 | SUMO specific peptidase 5. | USP domain-containing protein. | 0.731 |
SUMO2 | DESI1 | ENSGALP00000012928 | ENSGALP00000073779 | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | Desumoylating isopeptidase 1. | 0.674 |
SUMO2 | DESI2 | ENSGALP00000012928 | ENSGALP00000017350 | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | Deubiquitinase DESI2; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. | 0.577 |