node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | ATR | ENSGALP00000027660 | ENSGALP00000004185 | Non-specific serine/threonine protein kinase. | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.999 |
ATM | BRCA1 | ENSGALP00000027660 | ENSGALP00000004383 | Non-specific serine/threonine protein kinase. | Uncharacterized protein. | 0.999 |
ATM | EXO1 | ENSGALP00000027660 | ENSGALP00000017465 | Non-specific serine/threonine protein kinase. | Uncharacterized protein. | 0.974 |
ATM | MRE11 | ENSGALP00000027660 | ENSGALP00000027766 | Non-specific serine/threonine protein kinase. | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] | 0.997 |
ATM | NBN | ENSGALP00000027660 | ENSGALP00000056425 | Non-specific serine/threonine protein kinase. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] | 0.999 |
ATM | RAD50 | ENSGALP00000027660 | ENSGALP00000039135 | Non-specific serine/threonine protein kinase. | Zinc-hook domain-containing protein. | 0.994 |
ATM | RBBP8 | ENSGALP00000027660 | ENSGALP00000024123 | Non-specific serine/threonine protein kinase. | RB binding protein 8, endonuclease. | 0.846 |
ATM | WRN | ENSGALP00000027660 | ENSGALP00000068726 | Non-specific serine/threonine protein kinase. | Uncharacterized protein. | 0.956 |
ATM | XRCC5 | ENSGALP00000027660 | ENSGALP00000068401 | Non-specific serine/threonine protein kinase. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.935 |
ATM | XRCC6 | ENSGALP00000027660 | ENSGALP00000053314 | Non-specific serine/threonine protein kinase. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] | 0.987 |
ATR | ATM | ENSGALP00000004185 | ENSGALP00000027660 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Non-specific serine/threonine protein kinase. | 0.999 |
ATR | BRCA1 | ENSGALP00000004185 | ENSGALP00000004383 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Uncharacterized protein. | 0.980 |
ATR | EXO1 | ENSGALP00000004185 | ENSGALP00000017465 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Uncharacterized protein. | 0.919 |
ATR | MRE11 | ENSGALP00000004185 | ENSGALP00000027766 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] | 0.986 |
ATR | NBN | ENSGALP00000004185 | ENSGALP00000056425 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] | 0.951 |
ATR | RAD50 | ENSGALP00000004185 | ENSGALP00000039135 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Zinc-hook domain-containing protein. | 0.978 |
ATR | RBBP8 | ENSGALP00000004185 | ENSGALP00000024123 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | RB binding protein 8, endonuclease. | 0.760 |
ATR | WRN | ENSGALP00000004185 | ENSGALP00000068726 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Uncharacterized protein. | 0.985 |
ATR | XRCC5 | ENSGALP00000004185 | ENSGALP00000068401 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.731 |
ATR | XRCC6 | ENSGALP00000004185 | ENSGALP00000053314 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] | 0.787 |