node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTK | GNA11 | ENSGALP00000045102 | ENSGALP00000005115 | Tyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker prote [...] | Guanine nucleotide-binding protein G11 alpha-subunit. | 0.712 |
BTK | GNAQ | ENSGALP00000045102 | ENSGALP00000024446 | Tyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker prote [...] | Uncharacterized protein. | 0.709 |
BTK | P2RY6 | ENSGALP00000045102 | ENSGALP00000070498 | Tyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker prote [...] | P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.532 |
BTK | WASL | ENSGALP00000045102 | ENSGALP00000014285 | Tyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker prote [...] | Uncharacterized protein. | 0.543 |
ERP27 | P2RY6 | ENSGALP00000062955 | ENSGALP00000070498 | Endoplasmic reticulum protein 27. | P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.538 |
GNA11 | BTK | ENSGALP00000005115 | ENSGALP00000045102 | Guanine nucleotide-binding protein G11 alpha-subunit. | Tyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker prote [...] | 0.712 |
GNA11 | GNAQ | ENSGALP00000005115 | ENSGALP00000024446 | Guanine nucleotide-binding protein G11 alpha-subunit. | Uncharacterized protein. | 0.902 |
GNA11 | P2RY6 | ENSGALP00000005115 | ENSGALP00000070498 | Guanine nucleotide-binding protein G11 alpha-subunit. | P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.614 |
GNA11 | RGS18 | ENSGALP00000005115 | ENSGALP00000003996 | Guanine nucleotide-binding protein G11 alpha-subunit. | RGS domain-containing protein. | 0.606 |
GNAQ | BTK | ENSGALP00000024446 | ENSGALP00000045102 | Uncharacterized protein. | Tyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker prote [...] | 0.709 |
GNAQ | GNA11 | ENSGALP00000024446 | ENSGALP00000005115 | Uncharacterized protein. | Guanine nucleotide-binding protein G11 alpha-subunit. | 0.902 |
GNAQ | P2RY6 | ENSGALP00000024446 | ENSGALP00000070498 | Uncharacterized protein. | P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.542 |
GNAQ | RGS18 | ENSGALP00000024446 | ENSGALP00000003996 | Uncharacterized protein. | RGS domain-containing protein. | 0.606 |
GPR63 | P2RX2 | ENSGALP00000025057 | ENSGALP00000063943 | G protein-coupled receptor 63. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.582 |
GPR63 | P2RY6 | ENSGALP00000025057 | ENSGALP00000070498 | G protein-coupled receptor 63. | P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.630 |
GPR63 | WASL | ENSGALP00000025057 | ENSGALP00000014285 | G protein-coupled receptor 63. | Uncharacterized protein. | 0.528 |
P2RX1 | P2RX2 | ENSGALP00000034476 | ENSGALP00000063943 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.613 |
P2RX1 | P2RY6 | ENSGALP00000034476 | ENSGALP00000070498 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.790 |
P2RX2 | GPR63 | ENSGALP00000063943 | ENSGALP00000025057 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | G protein-coupled receptor 63. | 0.582 |
P2RX2 | P2RX1 | ENSGALP00000063943 | ENSGALP00000034476 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | 0.613 |