node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA2 | PINK1 | ENSGALP00000053550 | ENSGALP00000047654 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | PTEN induced kinase 1. | 0.565 |
ACAA2 | SIRT1 | ENSGALP00000053550 | ENSGALP00000004350 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Deacetylase sirtuin-type domain-containing protein. | 0.494 |
ACAA2 | SIRT2 | ENSGALP00000053550 | ENSGALP00000044776 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Deacetylase sirtuin-type domain-containing protein. | 0.493 |
ACAA2 | TGFBR3 | ENSGALP00000053550 | ENSGALP00000032713 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Transforming growth factor-beta type III receptor. | 0.571 |
ACVR1 | TGFB1 | ENSGALP00000046833 | ENSGALP00000053940 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.749 |
ACVR1 | TGFB2 | ENSGALP00000046833 | ENSGALP00000031309 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.692 |
ACVR1 | TGFB3 | ENSGALP00000046833 | ENSGALP00000036912 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] | 0.712 |
ACVR1 | TGFBR1 | ENSGALP00000046833 | ENSGALP00000054311 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.800 |
ACVR1 | TGFBR2 | ENSGALP00000046833 | ENSGALP00000018634 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.595 |
ACVR1 | TGFBR3 | ENSGALP00000046833 | ENSGALP00000032713 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). | Transforming growth factor-beta type III receptor. | 0.475 |
PINK1 | ACAA2 | ENSGALP00000047654 | ENSGALP00000053550 | PTEN induced kinase 1. | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.565 |
PINK1 | SIRT1 | ENSGALP00000047654 | ENSGALP00000004350 | PTEN induced kinase 1. | Deacetylase sirtuin-type domain-containing protein. | 0.639 |
PINK1 | SIRT2 | ENSGALP00000047654 | ENSGALP00000044776 | PTEN induced kinase 1. | Deacetylase sirtuin-type domain-containing protein. | 0.584 |
PINK1 | TGFBR3 | ENSGALP00000047654 | ENSGALP00000032713 | PTEN induced kinase 1. | Transforming growth factor-beta type III receptor. | 0.531 |
SIRT1 | ACAA2 | ENSGALP00000004350 | ENSGALP00000053550 | Deacetylase sirtuin-type domain-containing protein. | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.494 |
SIRT1 | PINK1 | ENSGALP00000004350 | ENSGALP00000047654 | Deacetylase sirtuin-type domain-containing protein. | PTEN induced kinase 1. | 0.639 |
SIRT1 | SIRT2 | ENSGALP00000004350 | ENSGALP00000044776 | Deacetylase sirtuin-type domain-containing protein. | Deacetylase sirtuin-type domain-containing protein. | 0.534 |
SIRT1 | TGFB1 | ENSGALP00000004350 | ENSGALP00000053940 | Deacetylase sirtuin-type domain-containing protein. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.454 |
SIRT1 | TGFBR3 | ENSGALP00000004350 | ENSGALP00000032713 | Deacetylase sirtuin-type domain-containing protein. | Transforming growth factor-beta type III receptor. | 0.577 |
SIRT2 | ACAA2 | ENSGALP00000044776 | ENSGALP00000053550 | Deacetylase sirtuin-type domain-containing protein. | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.493 |